DC Field | Value | Language |
---|---|---|
dc.contributor.author | S L Yoon | - |
dc.contributor.author | D C Kim | - |
dc.contributor.author | S H Cho | - |
dc.contributor.author | Sang-Yeop Lee | - |
dc.contributor.author | In-Sun Chu | - |
dc.contributor.author | J Heo | - |
dc.contributor.author | S H Leem | - |
dc.date.accessioned | 2017-04-19T09:20:18Z | - |
dc.date.available | 2017-04-19T09:20:18Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1225-8687 | - |
dc.identifier.uri | 10.3858/BMBRep.2010.43.10.698 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9837 | - |
dc.description.abstract | In this study, we characterized two blocks of minisatellites in the 5' upstream region of the BORIS gene (BORIS-MS1, -MS2). BORIS-MS2 was found to be polymorphic; therefore, this locus could be useful as a marker for DNA fingerprinting. We assessed the association between BORIS-MS2 and breast cancer by a case-control study with 428 controls and 793 breast cancers cases. Rare alleles in the younger group (age, <40) were associated with a statistically significant increased risk of breast cancer (odds ratio, 4.84; 95% confidence interval, 1.06-22.22; and P = 0.026). A statistically significant association between the short rare alleles and cancer was identified in the younger group (8.02; 1.01-63.83; P = 0.021). Kaplan-Meier estimates showed that poor prognosis was associated with patients who contained the rare alleles. Our data suggest that the short rare alleles of BORIS-MS2 could be used to identify the risk for breast cancer in young patients. | - |
dc.publisher | Korea Soc-Assoc-Inst | - |
dc.title | Susceptibility for breast cancer in young patients with short rare minisatellite alleles of BORIS | - |
dc.title.alternative | Susceptibility for breast cancer in young patients with short rare minisatellite alleles of BORIS | - |
dc.type | Article | - |
dc.citation.title | BMB Reports | - |
dc.citation.number | 10 | - |
dc.citation.endPage | 703 | - |
dc.citation.startPage | 698 | - |
dc.citation.volume | 43 | - |
dc.contributor.affiliatedAuthor | Sang-Yeop Lee | - |
dc.contributor.affiliatedAuthor | In-Sun Chu | - |
dc.contributor.alternativeName | 윤세련 | - |
dc.contributor.alternativeName | 김대철 | - |
dc.contributor.alternativeName | 조세헌 | - |
dc.contributor.alternativeName | 이상엽 | - |
dc.contributor.alternativeName | 추인선 | - |
dc.contributor.alternativeName | 허정훈 | - |
dc.contributor.alternativeName | 임선희 | - |
dc.identifier.bibliographicCitation | BMB Reports, vol. 43, no. 10, pp. 698-703 | - |
dc.identifier.doi | 10.3858/BMBRep.2010.43.10.698 | - |
dc.subject.keyword | BORIS | - |
dc.subject.keyword | Breast cancer | - |
dc.subject.keyword | Case-control study | - |
dc.subject.keyword | Minisatellite polymorphisms | - |
dc.subject.keyword | VNTR | - |
dc.subject.local | BORIS | - |
dc.subject.local | breast cancer | - |
dc.subject.local | Breast cancer | - |
dc.subject.local | Breast Cancer | - |
dc.subject.local | case-control study | - |
dc.subject.local | Case-control study | - |
dc.subject.local | Case control study | - |
dc.subject.local | Minisatellite polymorphisms | - |
dc.subject.local | VNTR | - |
dc.description.journalClass | Y | - |
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