Susceptibility for breast cancer in young patients with short rare minisatellite alleles of BORIS

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dc.contributor.authorS L Yoon-
dc.contributor.authorD C Kim-
dc.contributor.authorS H Cho-
dc.contributor.authorSang-Yeop Lee-
dc.contributor.authorIn-Sun Chu-
dc.contributor.authorJ Heo-
dc.contributor.authorS H Leem-
dc.date.accessioned2017-04-19T09:20:18Z-
dc.date.available2017-04-19T09:20:18Z-
dc.date.issued2010-
dc.identifier.issn1225-8687-
dc.identifier.uri10.3858/BMBRep.2010.43.10.698ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9837-
dc.description.abstractIn this study, we characterized two blocks of minisatellites in the 5' upstream region of the BORIS gene (BORIS-MS1, -MS2). BORIS-MS2 was found to be polymorphic; therefore, this locus could be useful as a marker for DNA fingerprinting. We assessed the association between BORIS-MS2 and breast cancer by a case-control study with 428 controls and 793 breast cancers cases. Rare alleles in the younger group (age, <40) were associated with a statistically significant increased risk of breast cancer (odds ratio, 4.84; 95% confidence interval, 1.06-22.22; and P = 0.026). A statistically significant association between the short rare alleles and cancer was identified in the younger group (8.02; 1.01-63.83; P = 0.021). Kaplan-Meier estimates showed that poor prognosis was associated with patients who contained the rare alleles. Our data suggest that the short rare alleles of BORIS-MS2 could be used to identify the risk for breast cancer in young patients.-
dc.publisherKorea Soc-Assoc-Inst-
dc.titleSusceptibility for breast cancer in young patients with short rare minisatellite alleles of BORIS-
dc.title.alternativeSusceptibility for breast cancer in young patients with short rare minisatellite alleles of BORIS-
dc.typeArticle-
dc.citation.titleBMB Reports-
dc.citation.number10-
dc.citation.endPage703-
dc.citation.startPage698-
dc.citation.volume43-
dc.contributor.affiliatedAuthorSang-Yeop Lee-
dc.contributor.affiliatedAuthorIn-Sun Chu-
dc.contributor.alternativeName윤세련-
dc.contributor.alternativeName김대철-
dc.contributor.alternativeName조세헌-
dc.contributor.alternativeName이상엽-
dc.contributor.alternativeName추인선-
dc.contributor.alternativeName허정훈-
dc.contributor.alternativeName임선희-
dc.identifier.bibliographicCitationBMB Reports, vol. 43, no. 10, pp. 698-703-
dc.identifier.doi10.3858/BMBRep.2010.43.10.698-
dc.subject.keywordBORIS-
dc.subject.keywordBreast cancer-
dc.subject.keywordCase-control study-
dc.subject.keywordMinisatellite polymorphisms-
dc.subject.keywordVNTR-
dc.subject.localBORIS-
dc.subject.localbreast cancer-
dc.subject.localBreast cancer-
dc.subject.localBreast Cancer-
dc.subject.localcase-control study-
dc.subject.localCase-control study-
dc.subject.localCase control study-
dc.subject.localMinisatellite polymorphisms-
dc.subject.localVNTR-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Metabolic Regulation Research Center > 1. Journal Articles
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