Synthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells

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dc.contributor.authorK Lee-
dc.contributor.authorJ H Lee-
dc.contributor.authorS K Boovanahalli-
dc.contributor.authorY Choi-
dc.contributor.authorSoo-Jin Choo-
dc.contributor.authorIck Dong Yoo-
dc.contributor.authorD H Kim-
dc.contributor.authorM Y Yun-
dc.contributor.authorG W Lee-
dc.contributor.authorG Y Song-
dc.date.accessioned2017-04-19T09:20:26Z-
dc.date.available2017-04-19T09:20:26Z-
dc.date.issued2010-
dc.identifier.issn0223-5234-
dc.identifier.uri10.1016/j.ejmech.2010.09.006ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9842-
dc.description.abstractWe report the synthesis of a novel series of highly potent melanin inhibitors which were obtained through structural modification of an anticancer compound S-(+)-decursinol. The in vitro inhibitory potencies of the newly synthesized compounds were evaluated against α-MSH induced melanin production in B16 murine melanoma cells. Among the compounds evaluated, compounds 2, 3, 6b, 7a, 7b, 8a and 8b emerged as highly potent inhibitors of melanin production. Besides, these compounds demonstrated significantly low cytotoxicity-
dc.publisherElsevier-
dc.titleSynthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells-
dc.title.alternativeSynthesis of (S)-(+)-decursin and its analogues as potent inhibitors of melanin formation in B16 murine melanoma cells-
dc.typeArticle-
dc.citation.titleEuropean Journal of Medicinal Chemistry-
dc.citation.number12-
dc.citation.endPage5575-
dc.citation.startPage5567-
dc.citation.volume45-
dc.contributor.affiliatedAuthorIck Dong Yoo-
dc.contributor.alternativeName이경-
dc.contributor.alternativeName이지현-
dc.contributor.alternativeNameBoovanahalli-
dc.contributor.alternativeName최용석-
dc.contributor.alternativeName추수진-
dc.contributor.alternativeName유익동-
dc.contributor.alternativeName김동희-
dc.contributor.alternativeName윤미영-
dc.contributor.alternativeName이계원-
dc.contributor.alternativeName송규용-
dc.identifier.bibliographicCitationEuropean Journal of Medicinal Chemistry, vol. 45, no. 12, pp. 5567-5575-
dc.identifier.doi10.1016/j.ejmech.2010.09.006-
dc.subject.keyword(+)-Decursin-
dc.subject.keyword(+)-Decursinol-
dc.subject.keyword(+)-Decursinol angelate-
dc.subject.keywordMelanin inhibitors-
dc.subject.local(+)-Decursin-
dc.subject.local(+)-Decursinol-
dc.subject.local(+)-Decursinol angelate-
dc.subject.localMelanin inhibitors-
dc.description.journalClassY-
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