Clavulanic acid biosynthesis and genetic manipulation for its overproduction

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Title
Clavulanic acid biosynthesis and genetic manipulation for its overproduction
Author(s)
Song Ju Yeon; S E Jensen; K J Lee
Bibliographic Citation
Applied Microbiology and Biotechnology, vol. 88, no. 3, pp. 659-669
Publication Year
2010
Abstract
Clavulanic acid, a β-lactamase inhibitor, is used together with β-lactam antibiotics to create drug mixtures possessing potent antimicrobial activity. In view of the clinical and industrial importance of clavulanic acid, identification of the clavulanic acid biosynthetic pathway and the associated gene cluster(s) in the main producer species, Streptomyces clavuligerus, has been an intriguing research question. Clavulanic acid biosynthesis was revealed to involve an interesting mechanism common to all of the clavam metabolites produced by the organism, but different from that of other β-lactam compounds. Gene clusters involved in clavulanic acid biosynthesis in S. clavuligerus occupy large regions of nucleotide sequence in three loci of its genome. In this review, clavulanic acid biosynthesis and the associated gene clusters are discussed, and clavulanic acid improvement through genetic manipulation is explained.
Keyword
β-lactam antibioticsClavamClavulanic acidStreptomyces clavuligerus
ISSN
0175-7598
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s00253-010-2801-2
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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