Inhibitory activities of Anthraquinones from Rubia akane on phosphatase regenerating liver-3 = 안스라큐논의 PRL-3 저해효과

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Title
Inhibitory activities of Anthraquinones from Rubia akane on phosphatase regenerating liver-3 = 안스라큐논의 PRL-3 저해효과
Author(s)
M K Moon; Young Min Han; Yu Jin Lee; L H Lee; J H Yang; Byoung-Mog Kwon; D K Kim
Bibliographic Citation
Archives of Pharmacal Research, vol. 33, no. 11, pp. 1747-1751
Publication Year
2010
Abstract
The methanolic extract of the roots of Rubia akane (Rubiaceae) was found to show inhibitory activity on phosphatase of regenerating liver-3 (PRL-3). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of two anthraquinone compounds, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(6'-O-acetyl)-α-rhamnosyl(1→2)-β-glucoside and 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone, as inhibitors on PRL-3. These compounds inhibited PRL-3 in a dose-dependent manner with IC50 values of 5.2 and 1.3 μg/mL, respectively.
Keyword
Rubia akaneRubiaceaeAnthraquinonePRL-3
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-010-1106-4
Type
Article
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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