Vitexin, orientin and other flavonoids from Spirodela polyrhiza inhibit adipogenesis in 3T3-L1 cells

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Title
Vitexin, orientin and other flavonoids from Spirodela polyrhiza inhibit adipogenesis in 3T3-L1 cells
Author(s)
J Kim; I Lee; J Seo; M Y Jung; Young-hee Kim; N Yim; K Bae
Bibliographic Citation
Phytotherapy Research, vol. 24, no. 10, pp. 1543-1548
Publication Year
2010
Abstract
To investigate the adipogenesis inhibitory effect on lipid accumulation, 3T3-L1 cells were treated with fractions and isolated flavonoids of Spirodela polyrhiza. An ethanol extract of S. polyrhiza was fractionated into three fractions. The butanol soluble fraction (SPB) exhibited potent antiadipogenesis activity and decreased C/EBPα and PPARγ protein expression level in 3T3-L1 cells without significant cytotoxicity. The flavonoids were isolated from SPB and their chemical structures were identified as chrysoeriol (1), apigenin (2), luteolin (3), vitexin (4), cosmosin (5), orientin (6) and luteolin-7-O-β-d-glucoside (7) by spectroscopic analysis. Studies on the adipogenesis and intracellular triglyceride accumulation inhibitory effect showed that compounds 4 and 6 had the highest activity and decreased C/EBPα and PPARγ protein expression level in 3T3-L1 cells. These results suggest that the flavonoids isolated from SPB, especially compounds 4 and 6, contribute to the inhibitory activity of S. polyrhiza in 3T3-L1 cells.
Keyword
3T3-L1adipogenesisflavonoidsorientinSpirodela polyrhizavitexin
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ptr.3186
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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