NMR characterization of oxidized form of human 8-kDa dynein light chain
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- Title
- NMR characterization of oxidized form of human 8-kDa dynein light chain
- Author(s)
- Jae-Sun Shin; W JEong; Seung-Wook Chi
- Bibliographic Citation
- Journal of Korean Magnetic Resonance Society, vol. 14, no. 2, pp. 127-133
- Publication Year
- 2010
- Abstract
- Redox-dependent conformational change of human 8-kDa Dynein light chain (LC8) plays important role in regulating NF-κB signaling pathway. In this study we characterized the structural states of the oxidized and reduced forms of LC8 by using NMR spectroscopy. The 1H-15N 2D HSQC spectra of oxidized LC8 indicated that no significant change in tertiary structure of LC8 occurred upon oxidation. The chemical shift perturbations of LC8 upon oxidation suggest a redox-dependent quaternary structural change.
- Keyword
- LC8NMRRedox changeDynein
- ISSN
- 1226-6531
- Publisher
- Korea Soc-Assoc-Inst
- Full Text Link
- http://dx.doi.org/10.6564/JKMRS.2010.14.2.127
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > 1. Journal Articles
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