NMR characterization of oxidized form of human 8-kDa dynein light chain

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Title
NMR characterization of oxidized form of human 8-kDa dynein light chain
Author(s)
Jae-Sun Shin; W JEong; Seung-Wook Chi
Bibliographic Citation
Journal of Korean Magnetic Resonance Society, vol. 14, no. 2, pp. 127-133
Publication Year
2010
Abstract
Redox-dependent conformational change of human 8-kDa Dynein light chain (LC8) plays important role in regulating NF-κB signaling pathway. In this study we characterized the structural states of the oxidized and reduced forms of LC8 by using NMR spectroscopy. The 1H-15N 2D HSQC spectra of oxidized LC8 indicated that no significant change in tertiary structure of LC8 occurred upon oxidation. The chemical shift perturbations of LC8 upon oxidation suggest a redox-dependent quaternary structural change.
Keyword
LC8NMRRedox changeDynein
ISSN
1226-6531
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.6564/JKMRS.2010.14.2.127
Type
Article
Appears in Collections:
Division of Biomedical Research > 1. Journal Articles
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