DDS, 4,4′-diaminodiphenylsulfone, extends organismic lifespan

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dc.contributor.authorS C Cho-
dc.contributor.authorM C Park-
dc.contributor.authorB Keam-
dc.contributor.authorJ M Choi-
dc.contributor.authorY Cho-
dc.contributor.authorSoonsil Hyun-
dc.contributor.authorS C Park-
dc.contributor.authorJ Lee-
dc.date.accessioned2017-04-19T09:20:55Z-
dc.date.available2017-04-19T09:20:55Z-
dc.date.issued2010-
dc.identifier.issn0027-8424-
dc.identifier.uri10.1073/pnas.1005078107ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9889-
dc.description.abstractDDS, 4,4′-diaminodiphenylsulfone, is the most common drug prescribed to treat Hansen disease patients. In addition to its antibacterial activity, DDS has been reported to be involved in other cellular processes that occur in eukaryotic cells. Because DDS treatment significantly enhances the antioxidant activity in humans, we examined its effect on lifespan extension. Here we show that DDS extends organismic lifespan using Caenorhabditis elegans as a model system. DDS treatment caused a delay in aging and decreased the levels of a mitochondrial complex. The oxygen consumption rate was also significantly lowered. Consistent with these data, paraquat treatment evoked less reactive oxygen species in DDS-treated worms, and these worms were less sensitive to paraquat. Interestingly enough, all of the molecular events caused by DDS treatment were consistently reproduced in mice treated with DDS for 3 mo and in the C2C12 muscle cell line. Structural prediction identified pyruvate kinase (PK) as a protein target of DDS. Indeed, DDS bound and inhibited PK in vitro and inhibited it in vivo, and a PK mutation conferred extended lifespan of C. elegans. Supplement of pyruvate to the media protected C2C12 cells from apoptosis caused by paraquat. Our findings establish the significance of DDS in lowering reactive oxygen species generation and extending the lifespan, which renders the rationale to examining the possible effect of DDS on human lifespan extension.-
dc.publisherNatl Acad Sciences-
dc.titleDDS, 4,4′-diaminodiphenylsulfone, extends organismic lifespan-
dc.title.alternativeDDS, 4,4′-diaminodiphenylsulfone, extends organismic lifespan-
dc.typeArticle-
dc.citation.titleProceedings of National Academy of Sciences of United States of America-
dc.citation.number45-
dc.citation.endPage19331-
dc.citation.startPage19326-
dc.citation.volume107-
dc.contributor.affiliatedAuthorSoonsil Hyun-
dc.contributor.alternativeName조성춘-
dc.contributor.alternativeName박문철-
dc.contributor.alternativeName김범석-
dc.contributor.alternativeName최정민-
dc.contributor.alternativeName조윤제-
dc.contributor.alternativeName현순실-
dc.contributor.alternativeName박상철-
dc.contributor.alternativeName이준호-
dc.identifier.bibliographicCitationProceedings of National Academy of Sciences of United States of America, vol. 107, no. 45, pp. 19326-19331-
dc.identifier.doi10.1073/pnas.1005078107-
dc.description.journalClassY-
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