Effect of AC-264, a novel indole derivative, on apoptosis in HL-60 cells
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- Effect of AC-264, a novel indole derivative, on apoptosis in HL-60 cells
- K Lee; Ok-Kyoung Kwon; Y Xia; Kyung Seop Ahn
- Bibliographic Citation
- Bulletin of Korean Chemical Society, vol. 31, no. 12, pp. 3777-3781
- Publication Year
- The anticancer effect and apoptotic mechanism of a novel indole derivative AC-264, a lead derived from a chemical library, were investigated in human promyelocytic leukemia HL-60 cells. HL-60 cells treated with AC-264 at various concentrations showed the morphological features of apoptosis, such as plasma membrane blebbing and cell shrinkage. AC-264 exhibited cytotoxic effect in various cancer cell lines with different degrees of potency. Especially, AC-264 was effective on increasing the population of apoptotic cells in HL-60 cells, as detected by the number of cells stained with Annexin V and PI. Furthermore, AC-264 activated caspase-3 enzyme activity and induced internucleosomal DNA fragmentation. These results indicated that AC-264 produces anti-cancer effect via apoptotic cell death by activating caspase-3 and inducing internucleosomal DNA fragmentation in HL-60 cells.
- Apoptosis; Caspase-3; DNA fragmentation; Indole derivative
- Appears in Collections:
- Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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