Effect of AC-264, a novel indole derivative, on apoptosis in HL-60 cells

Cited 1 time in scopus
Metadata Downloads
Title
Effect of AC-264, a novel indole derivative, on apoptosis in HL-60 cells
Author(s)
K Lee; Ok-Kyoung Kwon; Y Xia; Kyung Seop Ahn
Bibliographic Citation
Bulletin of Korean Chemical Society, vol. 31, no. 12, pp. 3777-3781
Publication Year
2010
Abstract
The anticancer effect and apoptotic mechanism of a novel indole derivative AC-264, a lead derived from a chemical library, were investigated in human promyelocytic leukemia HL-60 cells. HL-60 cells treated with AC-264 at various concentrations showed the morphological features of apoptosis, such as plasma membrane blebbing and cell shrinkage. AC-264 exhibited cytotoxic effect in various cancer cell lines with different degrees of potency. Especially, AC-264 was effective on increasing the population of apoptotic cells in HL-60 cells, as detected by the number of cells stained with Annexin V and PI. Furthermore, AC-264 activated caspase-3 enzyme activity and induced internucleosomal DNA fragmentation. These results indicated that AC-264 produces anti-cancer effect via apoptotic cell death by activating caspase-3 and inducing internucleosomal DNA fragmentation in HL-60 cells.
Keyword
ApoptosisCaspase-3DNA fragmentationIndole derivative
ISSN
0253-2964
Publisher
Wiley
DOI
http://dx.doi.org/10.5012/bkcs.2010.31.12.3777
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.