Open Access@KRIBBDivision of Bio Technology InnovationBioProcess Engineering Center1. Journal Articles
Suppression of proinflammatory cytokine production by specific metabolites of Lactobacillus plantarum 10hk2 via inhibiting NF-κB and p38 MAPK expressions
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | H Chon | - |
| dc.contributor.author | B Choi | - |
| dc.contributor.author | G Jeong | - |
| dc.contributor.author | Eun Gyo Lee | - |
| dc.contributor.author | S Lee | - |
| dc.date.accessioned | 2017-04-19T09:21:01Z | - |
| dc.date.available | 2017-04-19T09:21:01Z | - |
| dc.date.issued | 2010 | - |
| dc.identifier.issn | 0147-9571 | - |
| dc.identifier.uri | 10.1016/j.cimid.2009.11.002 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9915 | - |
| dc.description.abstract | The objective of this study was to evaluate the immunomodulatory effects of specific bacterial metabolites of Lactobacillus plantarum 10hk2 to induce anti-inflammatory mediators in cell cultures of the murine macrophage cell line, RAW 264.7. The effects of the extracellular metabolites of this bacterial strain were examined by dividing them into protein and polysaccharide fractions. A specific protein fraction (8.7. kDa) was found to be a strong IL-10 inducer in LPS-stimulated RAW 264.7 cells and suppressed LPS-induced NF-κB induction and inhibited LPS-induced phosphorylation of I-κB and p38 MAPK. To the best of our knowledge, this was the first study that investigated the anti-inflammatory effects of an extracellular peptide derived from lactic acid bacteria. In addition, we characterized the inhibitory mode of this molecule in the induction of proinflammatory cytokines. Based on the findings presented in this study, this molecule holds promise for use as an agent to modulate inflammation related diseases. | - |
| dc.publisher | Elsevier | - |
| dc.title | Suppression of proinflammatory cytokine production by specific metabolites of Lactobacillus plantarum 10hk2 via inhibiting NF-κB and p38 MAPK expressions | - |
| dc.title.alternative | Suppression of proinflammatory cytokine production by specific metabolites of Lactobacillus plantarum 10hk2 via inhibiting NF-κB and p38 MAPK expressions | - |
| dc.type | Article | - |
| dc.citation.title | Comparative Immunology Microbiology and Infectious Diseases | - |
| dc.citation.number | 6 | - |
| dc.citation.endPage | e49 | - |
| dc.citation.startPage | e41 | - |
| dc.citation.volume | 33 | - |
| dc.contributor.affiliatedAuthor | Eun Gyo Lee | - |
| dc.contributor.alternativeName | 전희선 | - |
| dc.contributor.alternativeName | 최병열 | - |
| dc.contributor.alternativeName | 정가진 | - |
| dc.contributor.alternativeName | 이은교 | - |
| dc.contributor.alternativeName | 이승희 | - |
| dc.identifier.bibliographicCitation | Comparative Immunology Microbiology and Infectious Diseases, vol. 33, no. 6, pp. e41-e49 | - |
| dc.identifier.doi | 10.1016/j.cimid.2009.11.002 | - |
| dc.subject.keyword | Anti-inflammation | - |
| dc.subject.keyword | IL-10 | - |
| dc.subject.keyword | Lactic acid bacteria | - |
| dc.subject.keyword | NF-κB | - |
| dc.subject.keyword | P38 MAPK | - |
| dc.subject.keyword | RAW 264.7 cells | - |
| dc.subject.local | Anti-inflammation | - |
| dc.subject.local | Antiinflammation | - |
| dc.subject.local | anti-inflammation | - |
| dc.subject.local | Anti-Inflammation | - |
| dc.subject.local | antiinflammation | - |
| dc.subject.local | IL-10 | - |
| dc.subject.local | Lactic acid bacteria | - |
| dc.subject.local | lactic acid bacteria | - |
| dc.subject.local | lacti acid bateria | - |
| dc.subject.local | NFkappaB | - |
| dc.subject.local | NFκB | - |
| dc.subject.local | Nf-κB | - |
| dc.subject.local | Nf-κb | - |
| dc.subject.local | Nuclear factor (NF)-κB | - |
| dc.subject.local | Nuclear factor kappa B | - |
| dc.subject.local | Nuclear factor kappaB | - |
| dc.subject.local | Nuclear factor κB | - |
| dc.subject.local | Nuclear factor κB (NF-κB) | - |
| dc.subject.local | Nuclear factor-kappa B | - |
| dc.subject.local | Nuclear factor-kappa B (NF-κB) | - |
| dc.subject.local | Nuclear factor-kappaB | - |
| dc.subject.local | Nuclear factor-κB | - |
| dc.subject.local | Nuclear factor-κb | - |
| dc.subject.local | NF-kB | - |
| dc.subject.local | NF-kappa B | - |
| dc.subject.local | NF-kappaB | - |
| dc.subject.local | NF-ΚB | - |
| dc.subject.local | NF-κ B | - |
| dc.subject.local | NF-κB | - |
| dc.subject.local | NF-κB (nuclear factor kappa-B) | - |
| dc.subject.local | nuclear factor kappa B | - |
| dc.subject.local | nuclear factor κB | - |
| dc.subject.local | nuclear factor-kappaB | - |
| dc.subject.local | nuclear factor-kappaB (NF-κB) | - |
| dc.subject.local | nuclear factor-κB | - |
| dc.subject.local | nuclear factorκB | - |
| dc.subject.local | P38 MAPK | - |
| dc.subject.local | p38 MAP kinase | - |
| dc.subject.local | p38 MAPK | - |
| dc.subject.local | p38 mitogen-activated protein kinase | - |
| dc.subject.local | p38 mitogen-activated protein kinase (p38 MARK) | - |
| dc.subject.local | p38MAPK | - |
| dc.subject.local | RAW 264.7 cells | - |
| dc.subject.local | RAW 264·7 cells | - |
| dc.description.journalClass | Y | - |
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