Suppression of proinflammatory cytokine production by specific metabolites of Lactobacillus plantarum 10hk2 via inhibiting NF-κB and p38 MAPK expressions

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dc.contributor.authorH Chon-
dc.contributor.authorB Choi-
dc.contributor.authorG Jeong-
dc.contributor.authorEun Gyo Lee-
dc.contributor.authorS Lee-
dc.date.accessioned2017-04-19T09:21:01Z-
dc.date.available2017-04-19T09:21:01Z-
dc.date.issued2010-
dc.identifier.issn0147-9571-
dc.identifier.uri10.1016/j.cimid.2009.11.002ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9915-
dc.description.abstractThe objective of this study was to evaluate the immunomodulatory effects of specific bacterial metabolites of Lactobacillus plantarum 10hk2 to induce anti-inflammatory mediators in cell cultures of the murine macrophage cell line, RAW 264.7. The effects of the extracellular metabolites of this bacterial strain were examined by dividing them into protein and polysaccharide fractions. A specific protein fraction (8.7. kDa) was found to be a strong IL-10 inducer in LPS-stimulated RAW 264.7 cells and suppressed LPS-induced NF-κB induction and inhibited LPS-induced phosphorylation of I-κB and p38 MAPK. To the best of our knowledge, this was the first study that investigated the anti-inflammatory effects of an extracellular peptide derived from lactic acid bacteria. In addition, we characterized the inhibitory mode of this molecule in the induction of proinflammatory cytokines. Based on the findings presented in this study, this molecule holds promise for use as an agent to modulate inflammation related diseases.-
dc.publisherElsevier-
dc.titleSuppression of proinflammatory cytokine production by specific metabolites of Lactobacillus plantarum 10hk2 via inhibiting NF-κB and p38 MAPK expressions-
dc.title.alternativeSuppression of proinflammatory cytokine production by specific metabolites of Lactobacillus plantarum 10hk2 via inhibiting NF-κB and p38 MAPK expressions-
dc.typeArticle-
dc.citation.titleComparative Immunology Microbiology and Infectious Diseases-
dc.citation.number6-
dc.citation.endPagee49-
dc.citation.startPagee41-
dc.citation.volume33-
dc.contributor.affiliatedAuthorEun Gyo Lee-
dc.contributor.alternativeName전희선-
dc.contributor.alternativeName최병열-
dc.contributor.alternativeName정가진-
dc.contributor.alternativeName이은교-
dc.contributor.alternativeName이승희-
dc.identifier.bibliographicCitationComparative Immunology Microbiology and Infectious Diseases, vol. 33, no. 6, pp. e41-e49-
dc.identifier.doi10.1016/j.cimid.2009.11.002-
dc.subject.keywordAnti-inflammation-
dc.subject.keywordIL-10-
dc.subject.keywordLactic acid bacteria-
dc.subject.keywordNF-κB-
dc.subject.keywordP38 MAPK-
dc.subject.keywordRAW 264.7 cells-
dc.subject.localantiinflammation-
dc.subject.localAntiinflammation-
dc.subject.localanti-inflammation-
dc.subject.localAnti-Inflammation-
dc.subject.localAnti-inflammation-
dc.subject.localIL-10-
dc.subject.localLactic acid bacteria-
dc.subject.locallactic acid bacteria-
dc.subject.localNuclear factor-kappa B-
dc.subject.localnuclear factor κB-
dc.subject.localNf-κb-
dc.subject.localNF-kB-
dc.subject.localnuclear factor kappa B-
dc.subject.localNF-κB (nuclear factor kappa-B)-
dc.subject.localNF-kappaB-
dc.subject.localNuclear factor-κb-
dc.subject.localNF-κ B-
dc.subject.localNF-κB-
dc.subject.localNF-kappa B-
dc.subject.localNuclear factor κB (NF-κB)-
dc.subject.localNuclear factor κB-
dc.subject.localNFκB-
dc.subject.localNf-κB-
dc.subject.localNuclear factor-κB-
dc.subject.localnuclear factorκB-
dc.subject.localNuclear factor (NF)-κB-
dc.subject.localNuclear factor kappa B-
dc.subject.localnuclear factor-κB-
dc.subject.localNF-ΚB-
dc.subject.localNuclear factor-kappa B (NF-κB)-
dc.subject.localNuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB-
dc.subject.localnuclear factor-kappaB (NF-κB)-
dc.subject.localNFkappaB-
dc.subject.localNuclear factor kappaB-
dc.subject.localp38 MAP kinase-
dc.subject.localp38 mitogen-activated protein kinase (p38 MARK)-
dc.subject.localP38 MAPK-
dc.subject.localp38 mitogen-activated protein kinase-
dc.subject.localp38 MAPK-
dc.subject.localp38MAPK-
dc.subject.localRAW 264·7 cells-
dc.subject.localRAW 264.7 cells-
dc.description.journalClassY-
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Division of Bio Technology Innovation > BioProcess Engineering Center > 1. Journal Articles
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