DC Field | Value | Language |
---|---|---|
dc.contributor.author | Young Min Han | - |
dc.contributor.author | Dae Seop Shin | - |
dc.contributor.author | Y J Lee | - |
dc.contributor.author | S A Ismail | - |
dc.contributor.author | S H Hong | - |
dc.contributor.author | Dong Cho Han | - |
dc.contributor.author | Byoung-Mog Kwon | - |
dc.date.accessioned | 2017-04-19T09:21:09Z | - |
dc.date.available | 2017-04-19T09:21:09Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | 10.1016/j.bmcl.2010.11.114 | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9928 | - |
dc.description.abstract | 2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI50 value of 7 μM, while the parent compounds, HCA and curcumin, displayed GI50 values of 12 and 30 μM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase. | - |
dc.publisher | Elsevier | - |
dc.title | 2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway = 하드록시 커큐미노이드에 의한 암세포 사멸 기전 규명 | - |
dc.title.alternative | 2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway | - |
dc.type | Article | - |
dc.citation.title | Bioorganic & Medicinal Chemistry Letters | - |
dc.citation.number | 2 | - |
dc.citation.endPage | 751 | - |
dc.citation.startPage | 747 | - |
dc.citation.volume | 21 | - |
dc.contributor.affiliatedAuthor | Young Min Han | - |
dc.contributor.affiliatedAuthor | Dae Seop Shin | - |
dc.contributor.affiliatedAuthor | Y J Lee | - |
dc.contributor.affiliatedAuthor | Dong Cho Han | - |
dc.contributor.affiliatedAuthor | Byoung-Mog Kwon | - |
dc.contributor.alternativeName | 한영민 | - |
dc.contributor.alternativeName | 신대섭 | - |
dc.contributor.alternativeName | 이유진 | - |
dc.contributor.alternativeName | Ismail | - |
dc.contributor.alternativeName | 홍수형 | - |
dc.contributor.alternativeName | 한동초 | - |
dc.contributor.alternativeName | 권병목 | - |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 2, pp. 747-751 | - |
dc.identifier.doi | 10.1016/j.bmcl.2010.11.114 | - |
dc.subject.keyword | Apoptosis | - |
dc.subject.keyword | Curcuminoid | - |
dc.subject.keyword | Hydroxycinnamaldehyde | - |
dc.subject.keyword | Reactive oxygen species | - |
dc.subject.local | apoptosis | - |
dc.subject.local | Apoptosis | - |
dc.subject.local | Curcuminoids | - |
dc.subject.local | Curcuminoid | - |
dc.subject.local | curcuminoids | - |
dc.subject.local | Hydroxycinnamaldehyde | - |
dc.subject.local | hydroxycinnamaldehyde | - |
dc.subject.local | Reactive oxidative species | - |
dc.subject.local | Reactive oxygen species(ROS) | - |
dc.subject.local | Reactive oxygen species | - |
dc.subject.local | Reactive Oxygen Species (ROS) | - |
dc.subject.local | Reactive Oxygen Species | - |
dc.subject.local | ROS | - |
dc.subject.local | Reactive oxygen species (ROS) | - |
dc.subject.local | reactive oxygen species | - |
dc.subject.local | reactive oxygen species (ROS) | - |
dc.description.journalClass | Y | - |
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