2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway = 하드록시 커큐미노이드에 의한 암세포 사멸 기전 규명

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dc.contributor.authorYoung Min Han-
dc.contributor.authorDae Seop Shin-
dc.contributor.authorY J Lee-
dc.contributor.authorS A Ismail-
dc.contributor.authorS H Hong-
dc.contributor.authorDong Cho Han-
dc.contributor.authorByoung-Mog Kwon-
dc.date.accessioned2017-04-19T09:21:09Z-
dc.date.available2017-04-19T09:21:09Z-
dc.date.issued2011-
dc.identifier.issn0960894X-
dc.identifier.uri10.1016/j.bmcl.2010.11.114ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9928-
dc.description.abstract2-Hydroxycinnamaldehyde (HCA) and curcumin have been reported to have antitumor effects against various human tumor cells in vitro and in vivo by generation of ROS. Aldehyde-free HCA analogs were synthesized based on the structure of curcumin, which we have called 2-hydroxycurcuminoids. The hydroxyl group of curcuminoids enhances the ability to generate ROS. 2-Hydroxycurcuminoid (HCC-7) strongly inhibited the growth of SW620 colon tumor cells with a GI50 value of 7 μM, while the parent compounds, HCA and curcumin, displayed GI50 values of 12 and 30 μM, respectively. HCC-7 was found to induce apoptosis through the reactive oxygen species-mitochondria pathway and cell cycle arrest at G2/M phase.-
dc.publisherElsevier-
dc.title2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway = 하드록시 커큐미노이드에 의한 암세포 사멸 기전 규명-
dc.title.alternative2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway-
dc.typeArticle-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.number2-
dc.citation.endPage751-
dc.citation.startPage747-
dc.citation.volume21-
dc.contributor.affiliatedAuthorY J Lee-
dc.contributor.affiliatedAuthorDong Cho Han-
dc.contributor.affiliatedAuthorByoung-Mog Kwon-
dc.contributor.alternativeName한영민-
dc.contributor.alternativeName신대섭-
dc.contributor.alternativeName이유진-
dc.contributor.alternativeNameIsmail-
dc.contributor.alternativeName홍수형-
dc.contributor.alternativeName한동초-
dc.contributor.alternativeName권병목-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, vol. 21, no. 2, pp. 747-751-
dc.identifier.doi10.1016/j.bmcl.2010.11.114-
dc.subject.keywordApoptosis-
dc.subject.keywordCurcuminoid-
dc.subject.keywordHydroxycinnamaldehyde-
dc.subject.keywordReactive oxygen species-
dc.subject.localApoptosis-
dc.subject.localCurcuminoid-
dc.subject.localHydroxycinnamaldehyde-
dc.subject.localReactive oxygen species-
dc.subject.localReactive oxygen species (ROS)-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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