Optimization of production yield for neohesperidin by response surface methodology = 반응표면분석법을 이용한 neohesperidin 생산 수율의 최적화

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Title
Optimization of production yield for neohesperidin by response surface methodology = 반응표면분석법을 이용한 neohesperidin 생산 수율의 최적화
Author(s)
Hee Jong Yang; Seong Yoep Jeong; N S Choi; Keug Hyun Ahn; Chan Sun Park; Byung Dae Yoon; Y W Ryu; S C Ahn; Min-Soo Kim
Bibliographic Citation
Journal of Life Science, vol. 20, no. 11, pp. 1691-1696
Publication Year
2010
Abstract
Neohesperidin is a natural new nutrition sweetener, widely existing in plants of dry citrus peel, which can be derived from extraction. Since the sweetness is 1,300-1,500 times greater than that of sugar, neohesperidin are widely used in fruit juices, wines, beverages, bakeries and pharmaceutical formulations, and are particularly suitable for consumption by diabetic patients. However, the yield of extraction from citrus peel waste is very low. In this study optimal yield conditions were determined using response surface methodology (RSM) in order to increase the neohesperidin extraction yield. The critical factors for maximum extraction yield were selected extraction pressure (x1), extraction time (x2), and concentration of ethanol (x3). As a result, the extraction yield was improved when the extracting pressure increased. The extraction yield also increased in a time-dependent manner. When adding ethanol as an assistance solvent to the supercritical carbon dioxide, extraction yield was increased as more ethanol concentration was added. Finally, the extraction yield of neohesperidin was improved to about 162.22% compared to ethanol extraction as a conventional method.
Keyword
Neohesperidinresponse surface methodologycitrus unshiucentral composite design
ISSN
I000-0128
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.5352/JLS.2010.20.11.1691
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Microbial Biotechnology Research Center > 1. Journal Articles
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