Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5

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dc.contributor.authorYong Sam Kim-
dc.contributor.authorJee Ae Jung-
dc.contributor.authorH J Kim-
dc.contributor.authorY H Ahn-
dc.contributor.authorJ S Yoo-
dc.contributor.authorS Oh-
dc.contributor.authorChang-Hee Cho-
dc.contributor.authorHyang Sook Yoo-
dc.contributor.authorJeong Heon Ko-
dc.date.accessioned2017-04-19T09:21:13Z-
dc.date.available2017-04-19T09:21:13Z-
dc.date.issued2011-
dc.identifier.issn0006-291X-
dc.identifier.uri10.1016/j.bbrc.2010.11.071ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9941-
dc.description.abstractIt has previously been reported that shedding of the PTPκ ectodomain drives enhanced motility of colon cancer cells. Herein, we provide mechanism underlying the regulation of PTPκ shedding by galectin-3 binding protein. PTPκ was inarguably scissored by the processed form of proprotein convertase 5 (subtilisin/kexin type 5), and galectin-3 binding protein which is over-produced in colon cancer cells and tissues contributed to increased cancer cell motility by acting as a negative regulator of galectin-3 at the cell surface. The high expression ratio of galectin-3 binding protein to galectin-3 was clinically correlated to lymphatic invasion. These results suggest that galectin-3 binding protein may be a potential therapeutic target for treatment of, at least, colon cancer patients with high expression of galectin-3 binding protein.-
dc.publisherElsevier-
dc.titleGalectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5-
dc.title.alternativeGalectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5-
dc.typeArticle-
dc.citation.titleBiochemical and Biophysical Research Communications-
dc.citation.number1-
dc.citation.endPage102-
dc.citation.startPage96-
dc.citation.volume404-
dc.contributor.affiliatedAuthorYong Sam Kim-
dc.contributor.affiliatedAuthorJee Ae Jung-
dc.contributor.affiliatedAuthorChang-Hee Cho-
dc.contributor.affiliatedAuthorHyang Sook Yoo-
dc.contributor.affiliatedAuthorJeong Heon Ko-
dc.contributor.alternativeName김용삼-
dc.contributor.alternativeName정지애-
dc.contributor.alternativeName김현정-
dc.contributor.alternativeName안영희-
dc.contributor.alternativeName유종신-
dc.contributor.alternativeName오세정-
dc.contributor.alternativeName조창희-
dc.contributor.alternativeName유향숙-
dc.contributor.alternativeName고정헌-
dc.identifier.bibliographicCitationBiochemical and Biophysical Research Communications, vol. 404, no. 1, pp. 96-102-
dc.identifier.doi10.1016/j.bbrc.2010.11.071-
dc.subject.keywordGalectin-3-
dc.subject.keywordGalectin-3 binding protein-
dc.subject.keywordProprotein convertase 5-
dc.subject.keywordPTPκ shedding-
dc.subject.localGalectin-3-
dc.subject.localgalectin-3-
dc.subject.localGalectin-3 binding protein-
dc.subject.localProprotein convertase 5-
dc.subject.localPTPκ shedding-
dc.description.journalClassY-
Appears in Collections:
Synthetic Biology and Bioengineering Research Institute > Genome Editing Research Center > 1. Journal Articles
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