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- Title
- Galectin-3 binding protein promotes cell motility in colon cancer by stimulating the shedding of protein tyrosine phosphatase kappa by proprotein convertase 5
- Author(s)
- Yong Sam Kim; Jee Ae Jung; H J Kim; Y H Ahn; J S Yoo; S Oh; Chang-Hee Cho; Hyang Sook Yoo; Jeong Heon Ko
- Bibliographic Citation
- Biochemical and Biophysical Research Communications, vol. 404, no. 1, pp. 96-102
- Publication Year
- 2011
- Abstract
- It has previously been reported that shedding of the PTPκ ectodomain drives enhanced motility of colon cancer cells. Herein, we provide mechanism underlying the regulation of PTPκ shedding by galectin-3 binding protein. PTPκ was inarguably scissored by the processed form of proprotein convertase 5 (subtilisin/kexin type 5), and galectin-3 binding protein which is over-produced in colon cancer cells and tissues contributed to increased cancer cell motility by acting as a negative regulator of galectin-3 at the cell surface. The high expression ratio of galectin-3 binding protein to galectin-3 was clinically correlated to lymphatic invasion. These results suggest that galectin-3 binding protein may be a potential therapeutic target for treatment of, at least, colon cancer patients with high expression of galectin-3 binding protein.
- Keyword
- Galectin-3Galectin-3 binding proteinProprotein convertase 5PTPκ shedding
- ISSN
- 0006-291X
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1016/j.bbrc.2010.11.071
- Type
- Article
- Appears in Collections:
- Synthetic Biology and Bioengineering Research Institute > Genome Editing Research Center > 1. Journal Articles
- Files in This Item:
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