Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion

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Title
Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion
Author(s)
S S Rho; H J Choi; J K Min; H W Lee; H Park; H Park; Y M Kim; Y G Kwon
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 404, no. 1, pp. 103-108
Publication Year
2011
Abstract
Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell-cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell-cell adhesion and angiogenesis.
Keyword
C-type lectin like domainCell-cell adhesionClec14aEndothelial cellAngiogenesis
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2010.11.075
Type
Article
Appears in Collections:
Division of Biomedical Research > Biotherapeutics Translational Research Center > 1. Journal Articles
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