Oxygenated hexylitaconates from a marine sponge-derived fungus Penicillium sp.

Cited 20 time in scopus
Metadata Downloads
Title
Oxygenated hexylitaconates from a marine sponge-derived fungus Penicillium sp.
Author(s)
J L Li; P Zhang; Y M Lee; J Hong; E S Yoo; Kyung Sook Bae; J H Jung
Bibliographic Citation
Chemical & Pharmaceutical Bulletin, vol. 59, no. 1, pp. 120-123
Publication Year
2011
Abstract
In the course of our search for bioactive metabolites from marine organisms, new hexylitaconic acid derivatives (1-4), along with (3S)-hexylitaconic acid (5), were isolated from a sponge-derived fungus Penicillium sp. Based on the NMR and MS data, the structures of compounds 1-4 were defined as α,β-dicarboxylic acid derivatives, such as hexylitaconic acid and tensyuic acids which were previously reported as metabolite of Aspergillus niger, Penicillium striatisporum, or Apiospora montagnei. The isolated compounds were evaluated for cytotoxicity against a panel of five human solid tumor cell lines, and for anti-inflammatory activity gauged by their inhibitory effects on the production of major pro-inflammatory mediators (nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β) in murine macrophage cells. Compounds 1 and 4 showed weak inhibition of IL-1β production at the concentration of 200 μM.
Keyword
Anti-inflammatoryCytotoxicityDicarboxylic acidHexylitaconatePenicillium sp.Sponge-derived fungus
ISSN
0009-2363
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/cpb.59.120
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
Files in This Item:

Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.