Manassantin A and B from Saururus chinensis inhibit interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells

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dc.contributor.authorJong Sun Chang-
dc.contributor.authorSeung Woong Lee-
dc.contributor.authorM S Kim-
dc.contributor.authorBo Ra Yoon-
dc.contributor.authorMi-hye Park-
dc.contributor.authorS G Lee-
dc.contributor.authorSu-Jin Park-
dc.contributor.authorWoo Song Lee-
dc.contributor.authorMun Chual Rho-
dc.date.accessioned2017-04-19T09:21:23Z-
dc.date.available2017-04-19T09:21:23Z-
dc.date.issued2011-
dc.identifier.issn13478613-
dc.identifier.uri10.1254/jphs.10239SCko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/9963-
dc.description.abstractInhibition of interleukin-6 (IL-6) has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine potential effects of manassantin A and B isolated from Saururus chinensis on the IL-6-induced response to human hepatoma cells. We found that manassantin A and B inhibit signal transducer and activator of transcription 3 (Stat3) activity stimulated by IL-6. We also found that both compounds decreased IL-6-induced Stat3 phosphorylation and nuclear translocation. Both compounds blocked suppressor of cytokine signaling 3 (SOCS-3)-mRNA expression induced by IL-6. In addition, we found that Stat3 inhibitory effects of these compounds could be related to protein tyrosine phosphatase. These findings suggest that manassantin A and B could be useful remedies for treatment of inflammatory diseases by inhibiting IL-6 action.-
dc.publisherJapanese Pharmacological Soc-
dc.titleManassantin A and B from Saururus chinensis inhibit interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells-
dc.title.alternativeManassantin A and B from Saururus chinensis inhibit interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells-
dc.typeArticle-
dc.citation.titleJournal of Pharmacological Sciences-
dc.citation.number1-
dc.citation.endPage88-
dc.citation.startPage84-
dc.citation.volume115-
dc.contributor.affiliatedAuthorSeung Woong Lee-
dc.contributor.affiliatedAuthorSu-Jin Park-
dc.contributor.affiliatedAuthorWoo Song Lee-
dc.contributor.affiliatedAuthorMun Chual Rho-
dc.contributor.alternativeName장종선-
dc.contributor.alternativeName이승웅-
dc.contributor.alternativeName김묘선-
dc.contributor.alternativeName윤보라-
dc.contributor.alternativeName박미혜-
dc.contributor.alternativeName이석근-
dc.contributor.alternativeName박수진-
dc.contributor.alternativeName이우송-
dc.contributor.alternativeName노문철-
dc.identifier.bibliographicCitationJournal of Pharmacological Sciences, vol. 115, no. 1, pp. 84-88-
dc.identifier.doi10.1254/jphs.10239SC-
dc.subject.keywordInterleukin-6-
dc.subject.keywordManassantin A and B-
dc.subject.keywordSignal transducer and activator of transcription 3 (Stat3)-
dc.subject.localInterleukin-6-
dc.subject.localManassantin A and B-
dc.subject.localSignal transducer and activator of transcription 3 (Stat3)-
dc.subject.localSignal transducer and activator of transcription 3 (STAT3)-
dc.description.journalClassY-
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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