DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jong Sun Chang | - |
dc.contributor.author | Seung Woong Lee | - |
dc.contributor.author | M S Kim | - |
dc.contributor.author | Bo Ra Yoon | - |
dc.contributor.author | Mi-hye Park | - |
dc.contributor.author | S G Lee | - |
dc.contributor.author | Su-Jin Park | - |
dc.contributor.author | Woo Song Lee | - |
dc.contributor.author | Mun Chual Rho | - |
dc.date.accessioned | 2017-04-19T09:21:23Z | - |
dc.date.available | 2017-04-19T09:21:23Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1347-8613 | - |
dc.identifier.uri | 10.1254/jphs.10239SC | ko |
dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/9963 | - |
dc.description.abstract | Inhibition of interleukin-6 (IL-6) has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine potential effects of manassantin A and B isolated from Saururus chinensis on the IL-6-induced response to human hepatoma cells. We found that manassantin A and B inhibit signal transducer and activator of transcription 3 (Stat3) activity stimulated by IL-6. We also found that both compounds decreased IL-6-induced Stat3 phosphorylation and nuclear translocation. Both compounds blocked suppressor of cytokine signaling 3 (SOCS-3)-mRNA expression induced by IL-6. In addition, we found that Stat3 inhibitory effects of these compounds could be related to protein tyrosine phosphatase. These findings suggest that manassantin A and B could be useful remedies for treatment of inflammatory diseases by inhibiting IL-6 action. | - |
dc.publisher | Japanese Pharmacological Soc | - |
dc.title | Manassantin A and B from Saururus chinensis inhibit interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells | - |
dc.title.alternative | Manassantin A and B from Saururus chinensis inhibit interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells | - |
dc.type | Article | - |
dc.citation.title | Journal of Pharmacological Sciences | - |
dc.citation.number | 1 | - |
dc.citation.endPage | 88 | - |
dc.citation.startPage | 84 | - |
dc.citation.volume | 115 | - |
dc.contributor.affiliatedAuthor | Jong Sun Chang | - |
dc.contributor.affiliatedAuthor | Seung Woong Lee | - |
dc.contributor.affiliatedAuthor | Bo Ra Yoon | - |
dc.contributor.affiliatedAuthor | Mi-hye Park | - |
dc.contributor.affiliatedAuthor | Su-Jin Park | - |
dc.contributor.affiliatedAuthor | Woo Song Lee | - |
dc.contributor.affiliatedAuthor | Mun Chual Rho | - |
dc.contributor.alternativeName | 장종선 | - |
dc.contributor.alternativeName | 이승웅 | - |
dc.contributor.alternativeName | 김묘선 | - |
dc.contributor.alternativeName | 윤보라 | - |
dc.contributor.alternativeName | 박미혜 | - |
dc.contributor.alternativeName | 이석근 | - |
dc.contributor.alternativeName | 박수진 | - |
dc.contributor.alternativeName | 이우송 | - |
dc.contributor.alternativeName | 노문철 | - |
dc.identifier.bibliographicCitation | Journal of Pharmacological Sciences, vol. 115, no. 1, pp. 84-88 | - |
dc.identifier.doi | 10.1254/jphs.10239SC | - |
dc.subject.keyword | Interleukin-6 | - |
dc.subject.keyword | Manassantin A and B | - |
dc.subject.keyword | Signal transducer and activator of transcription 3 (Stat3) | - |
dc.subject.local | IL6 | - |
dc.subject.local | interukin -6 | - |
dc.subject.local | Interleukin-6 (IL-6) | - |
dc.subject.local | IL-6 | - |
dc.subject.local | Il-6 | - |
dc.subject.local | interleukin-6 | - |
dc.subject.local | interleukin-6 (IL-6) | - |
dc.subject.local | Interleukin-6 | - |
dc.subject.local | Manassantin A and B | - |
dc.subject.local | Signal transducer and activator of transcription 3 (STAT3) | - |
dc.subject.local | Signal transducer and activator of transcription | - |
dc.subject.local | Signal transducer and activator of transcription 3 (Stat3) | - |
dc.subject.local | STAT 3 | - |
dc.subject.local | STAT3 | - |
dc.subject.local | Signal transducer and activator of transcription 3 | - |
dc.subject.local | Stat3 | - |
dc.subject.local | Signal transducer and activator of transcription factor 3 (STAT3) | - |
dc.description.journalClass | Y | - |
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