Evaluation of immunotoxicity of shizukaol B isolated from Chloranthus japonicus

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Title
Evaluation of immunotoxicity of shizukaol B isolated from Chloranthus japonicus
Author(s)
S W Kwon; Young Kook Kim; J Y Kim; H S Ryu; H K Lee; Jong Soon Kang; Hwan Mook Kim; J T Hong; Y Kim; S B Han
Bibliographic Citation
Biomolecules & Therapeutics, vol. 19, no. 1, pp. 59-64
Publication Year
2011
Abstract
Dimeric sesquiterpenoid shizukaol B (SKB) was isolated from Chloranthus japonicus Sieb. Except that SKB inhibited adhesion molecule expression in monocytes and endothelial cells, no more biological and pharmacological activity of SKB had been reported until now. In this study, we examined immunosuppressive activity of SKB. SKB strongly inhibited lipopolysaccharide (LPS)- induced B cell proliferation with IC50 of 137 ng/ml, but slightly or not concanavalin A-induced T cell proliferation, LPS-induced macrophage NO production, and LPS-induced dendritic cell maturation. As a mechanism, SKB strongly induced apoptotic death of B cells, but not other cell types. These results suggested that SKB induced toxicity-mediated immunosuppression against B cells.
Keyword
B cellsChloranthus japonicusCytotoxicityImmunosuppressionShizukaol B
ISSN
1976-9148
Publisher
South Korea
DOI
http://dx.doi.org/10.4062/biomolther.2011.19.1.059
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of Bioinfrastructure > Laboratory Animal Resource Center > 1. Journal Articles
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