Anti-inflammatory diterpene from Thyrsanthera suborbicularis

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Title
Anti-inflammatory diterpene from Thyrsanthera suborbicularis
Author(s)
P Khiev; Sei Ryang Oh; Hee Sung Chae; Ok-Kyoung KwonKyung Seop Ahn; Y W Chin; Hyeong Kyu Lee
Bibliographic Citation
Chemical & Pharmaceutical Bulletin, vol. 59, no. 3, pp. 382-384
Publication Year
2011
Abstract
Bioactivity-guided isolation on a n-hexane-soluble fraction of Thyrsanthera suborbicularis led to the isolation of a new rosane-type diterpene, 19-hydroxy-1(10), 15-rosadiene (1), along with three known compounds, taraxerol, acetyl aleuritolic acid, and spathulenol. The structures of isolated compounds were determined by interpretation of NMR spectroscopic data and mass spectrometry. Compound 1 demonstrated significantly inhibitory activity on nitric oxide production in RAW264.7 lipopolysaccharide (LPS)-activated mouse macrophages with an IC50 value of 2.91 μg/ml via the suppression of inducible nitric oxide synthase (iNOS) mRNA expression.
Keyword
EuphorbiaceaeInducible nitric oxide synthaseNitric oxideRosane diterpenoidThyrsanthera suborbicularis
ISSN
0009-2363
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/cpb.59.382
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
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