Phenolic compounds isolated from Zingiber officinale roots inhibit cell adhesion = 건강으로부터 분리된 페놀릭 화합물의 세포접착 저해활성

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Title
Phenolic compounds isolated from Zingiber officinale roots inhibit cell adhesion = 건강으로부터 분리된 페놀릭 화합물의 세포접착 저해활성
Author(s)
Seung Woong Lee; J H Lim; M S Kim; J H Jeong; G Y Song; Woo Song LeeMun Chual Rho
Bibliographic Citation
Food Chemistry, vol. 128, no. 3, pp. 778-782
Publication Year
2011
Abstract
Inhibitors of cell adhesion molecule-mediated cell adhesion might be novel therapeutic agents for the treatment of various inflammatory diseases. In this study, nine phenolic compounds were isolated from the methanol extracts of Zingiber officinale roots by bioactivity-guided fractionation. The structures of the compounds were determined by spectroscopic analysis (1H, 13C NMR and MS), to be 6-gingerol (1), 8-gingerol (2), 10-gingerol (3), 6-shogaol (4), 8-shogaol (5), 10-shogaol (6), dehydro-6-gingerdione (7), dehydro-10-gingerdione (8) and 6-paradol (9). Compounds 3, 4, 5 and 7 inhibited direct binding between sICAM-1 and LFA-1 of the THP-1 cells in a dose-dependent manner with IC50 values of 57.6, 27.1, 65.4 and 62.0 μM, respectively. Compounds 4 and 7 had an inhibitory effect on direct binding between sVCAM-1 and VLA-4 of THP-1 cells. These results suggest that the phenolic compounds from Z. officinale roots are good candidates for therapeutic strategies aimed at inflammation.
Keyword
Cell adhesion moleculesGingerolsShogaolsTHP-1 cellsZingiber officinaleZingiberaceae
ISSN
0308-8146
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.foodchem.2011.03.095
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Immunoregulatory materials Research Center > 1. Journal Articles
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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