Protein expression analysis in hematopoietic stem cells during osteopontin-induced differentiation of natural killer cells

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Title
Protein expression analysis in hematopoietic stem cells during osteopontin-induced differentiation of natural killer cells
Author(s)
M S Kim; K S Bae; H J Kim; Suk Ran YoonDoo-Byoung Oh; K W Hwang; W J Jun; S I Shim; K D Kim; Y W Jung; S Y Park; Ki Sun Kwon; In Pyo Choi; J W Chung
Bibliographic Citation
Biomolecules & Therapeutics, vol. 19, no. 2, pp. 206-210
Publication Year
2011
Abstract
Natural Killer (NK) cells are the lymphocytes that are derived from hematopoietic stem cells, developed in the bone marrow from hematopoietic stem cells (HSC) by sequential acquisition of functional surface receptors, and express the repertoire of inhibitory and activating receptors. Recently, Osteopontin (OPN) has been identifi ed as a critical factor for differentiation of natural killer cells. However, the detailed mechanism of OPN-induced NK differentiation has been still to be elucidated. Here, we determined the signaling pathway and possible receptor for OPN in NK differentiation. OPN induced expression of Bcl-2 and activation of Erk kinase. Inhibition of Erk pathway decreased the effect of OPN on NK differentiation. In addition, the expression of integrin α9 was signifi cantly increased by OPN during NK differentiation, suggesting the possible role of a major signaling molecule for OPN- induced NK differentiation.
Keyword
ErkHematopoietic stem cellsNatural killer cellsOsteopontinBcl-2
ISSN
1976-9148
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4062/biomolther.2011.19.2.206
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
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