A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides

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Title
A FLT3-inhibitory constituent from the rhizomes of Anemarrhena asphodeloides
Author(s)
S Y Han; Young Won Chin
Bibliographic Citation
Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 26, no. 3, pp. 445-448
Publication Year
2011
Abstract
Bioactivity-guided investigation for the rhizomes of Anemarrhena asphodeloides using the Fms-like tyrosine kinase 3 (FLT3) inhibition assay led to the identification of an active xanthone, mangiferin. Mangiferin was found to inhibit activity of the FLT3 wild type and a mutated form of FLT3 with IC 50 values of 0.7 and 1.2μM, respectively. Furthermore, this compound was assessed with a small panel of select kinases anaplastic lymphoma kinase (ALK), insulin receptor, and epidermal growth factor receptor) and was also found to be active in ALK assay.
Keyword
ALKAnemarrhena asphodeloidesFLT3mangiferinxanthone
ISSN
1475-6366
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.3109/14756366.2010.515215
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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