PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase

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Title
PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase
Author(s)
Y Lee; Su Jin Kim; Hye-Jin Min; Ji Yoon Jo; E H Park; Sang Seok Koh
Bibliographic Citation
Experimental and Molecular Medicine, vol. 43, no. 5, pp. 291-297
Publication Year
2011
Abstract
Pancreatic cancer is a notorious disease with a poor prognosis and low survival rates, which is due to limited advances in understanding of the molecular mechanism and inadequate development of effective treatment options over the decades. In previous studies, we demonstrated that a novel soluble protein named pancreatic adenocarcinoma up-regulated factor (PAUF) acts on tumor and immune cells and plays an important role in metastasis and progression of pancreatic cancer. Here we show that PAUF promotes adhesiveness of pancreatic cancer cells to various extracellular matrix (ECM). Our results further support a positive correlation of activation and expression of focal adhesion kinase (FAK), a key player in tumor cell metastasis and survival, with PAUF expression. PAUF-mediated adhesiveness was significantly attenuated upon blockade of the FAK pathway. Moreover, PAUF appeared to enhance resistance of pancreatic cancer cells to anoikis via modulation of FAK. Our results suggest that PAUF-mediated FAK activation plays an important role in pancreatic cancer progression.
Keyword
AdhesionAnoikisFAKPancreatic cancerPAUFSignaling
ISSN
I000-0028
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.3858/emm.2011.43.5.030
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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