(-)-pinoresinol monomethyl ether inhibits LPS-induced iNOS and Cox-2 expression via the attenuation of NF-κb in Raw 264.7 macrophage cells

Cited 0 time in scopus
Metadata Downloads
Title
(-)-pinoresinol monomethyl ether inhibits LPS-induced iNOS and Cox-2 expression via the attenuation of NF-κb in Raw 264.7 macrophage cells
Author(s)
B Y Park; M Y Lee; Kyung Seop Ahn; Y W Chin; Hyeong Kyu Lee; Sei Ryang Oh
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 54, no. 2, pp. 163-168
Publication Year
2011
Abstract
Anti-inflammatory effects of (-)-pinoresinol monomethyl ether (PME) were evaluated on lipopolysaccharide (LPS)-treated Raw 264.7 macrophage cells. PME inhibited translocation of p65-nuclear factor-κB (NF-κB) into the nucleus in immunocytochemical analysis for NF-κB activation, expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in Western blotting, as well as production of pro-inflammatory mediators, such as nitric oxide (NO), tumor necrosis factor (TNF-α), and prostaglandin E2 (PGE2) in LPS-induced Raw 264.7 cells. These results suggest the anti-inflammatory activity of PME could be due to the down-regulation of iNOS, COX-2, TNF-α, and PGE2 in activated Raw 264.7 cells through NF-κB-dependent pathways.
Keyword
(-)-pinoresinol monomethyl etherCox-2Inducible nitric oxide synthaseNitric oxideNuclear factor-κbProstaglandin e2Tumor necrosis factor
ISSN
I000-0171
Publisher
Springer
DOI
http://dx.doi.org/10.3839/jksabc.2011.027
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.