A new xanthene from Desmostachya bipinnata (L.) stapf inhibits signal transducer and activator of transcription 3 (STAT3) and low-density lipoprotein-oxidation

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Title
A new xanthene from Desmostachya bipinnata (L.) stapf inhibits signal transducer and activator of transcription 3 (STAT3) and low-density lipoprotein-oxidation
Author(s)
S Shrestha; J H Park; D Y Lee; J G Cho; E Cui; I S Chung; Byoung-Mog Kwon; M H Cho; Tae Sook Jeong; N I Baek
Bibliographic Citation
Journal of Korean Society for Applied Biological Chemistry, vol. 54, no. 2, pp. 308-311
Publication Year
2011
Abstract
A new xanthene was isolated from the methanolic extract of Desmostachya bipinnnata through repeated silica gel and octadecyl silica gel column chromatographies. Based on spectroscopic data including nuclear magnetic resonance, fast atom bombardment mass spectrometry, and infrared spectroscopy, chemical structure of the compound was determined to be 2,6-dihydroxy-7-methoxy-3H-xanthen-3-one. The compound exhibited inhibitions of signal transducer and activator of transcription 3-dependent luciferase activity in HCT-116 colon cancer cell line with IC50 value of 5 μM and low-density lipoprotein-oxidation with IC50 value of 27.2 μM.
Keyword
2,6-dihydroxy-7-methoxy-3h-xanthen-3-oneDesmostatchya bipinnataLow-density lipoprotein-oxidationSignal transducer and activator of transcription
ISSN
I000-0171
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.3839/jksabc.2011.049
Type
Article
Appears in Collections:
Division of Biomedical Research > Microbiome Convergence Research Center > 1. Journal Articles
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