Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part I

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Title
Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part I
Author(s)
J S Yang; D Song; B Lee; W J Ko; S K Park; Mi Sun Won; K Lee; H M Kim; G Han
Bibliographic Citation
European Journal of Medicinal Chemistry, vol. 46, no. 7, pp. 2861-2866
Publication Year
2011
Abstract
We synthesized novel aliphatic amido-quaternary ammonium salts in an effort to discover anticancer agents that increase Ras homolog gene family, member B, (RhoB) levels. These compounds exert anti-proliferative activities against several human cancer cell types. Seventeen compounds, varying in aliphatic carbon chain length and N-substituents, were synthesized and their biological activities were evaluated. Of these 17 compounds, compound 3i emerged as the most promising anticancer compound by promoting apoptosis through the RhoB mediated pathway. Potent biological activities observed for these novel aliphatic amido-quaternary ammonium salt analogues support their potential as anticancer, chemotherapeutic agents.
Keyword
Aliphatic amido-quaternary ammonium saltsGTPase RAt Sarcoma (Ras)NSC126188PerifosinePiperazine alkyl derivativesRhoB
ISSN
0223-5234
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.ejmech.2011.04.009
Type
Article
Appears in Collections:
Division of Biomedical Research > Personalized Genomic Medicine Research Center > 1. Journal Articles
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