Biosynthesis of plant-specific phenylpropanoids by construction of an artificial biosynthetic pathway in Escherichia coli = 대장균에서 페닐프로판노이드 인공 생합성

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Title
Biosynthesis of plant-specific phenylpropanoids by construction of an artificial biosynthetic pathway in Escherichia coli = 대장균에서 페닐프로판노이드 인공 생합성
Author(s)
Oksik Choi; C Z Wu; Sun-Young Kang; Jong Seog Ahn; T B Uhm; Young-Soo Hong
Bibliographic Citation
Journal of Industrial Microbiology & Biotechnology, vol. 38, no. 10, pp. 1657-1665
Publication Year
2011
Abstract
Biological synthesis of plant secondary metabolites has attracted increasing attention due to their proven or assumed beneficial properties and health-promoting effects. Phenylpropanoids are the precursors to a range of important plant metabolites such as the secondary metabolites belonging to the flavonoid/stilbenoid class of compounds. In this study, engineered Escherichia coli containing artificial phenylpropanoid biosynthetic pathways utilizing tyrosine as the initial precursor were established for production of plant-specific metabolites such as ferulic acid, naringenin, and resveratrol. The construction of the artificial pathway utilized tyrosine ammonia lyase and 4-coumarate 3-hydroxylase from Saccharothrix espanaensis, cinnamate/4-coumarate:coenzyme A ligase from Streptomyces coelicolor, caffeic acid O-methyltransferase and chalcone synthase from Arabidopsis thaliana, and stilbene synthase from Arachis hypogaea.
Keyword
BiosynthesisPhenylpropanoidHeterologous expressionArtiWcial pathway
ISSN
0169-4146
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s10295-011-0954-3
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
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