CMOS image sensor for detection of interferon gamma protein interaction as a point-of-care approach

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Title
CMOS image sensor for detection of interferon gamma protein interaction as a point-of-care approach
Author(s)
M Marimuthu; K Kandasamy; C G Ahn; G Y Sung; Min-Gon Kim; S Kim
Bibliographic Citation
Analytical and Bioanalytical Chemistry, vol. 401, no. 5, pp. 1645-1653
Publication Year
2011
Abstract
Complementary metal oxide semiconductor (CMOS)-based image sensors have received increased attention owing to the possibility of incorporating them into portable diagnostic devices. The present research examined the efficiency and sensitivity of a CMOS image sensor for the detection of antigen-antibody interactions involving interferon gamma protein without the aid of expensive instruments. The highest detection sensitivity of about 1 fg/ml primary antibody was achieved simply by a transmission mechanism. When photons are prevented from hitting the sensor surface, a reduction in digital output occurs in which the number of photons hitting the sensor surface is approximately proportional to the digital number. Nanoscale variation in substrate thickness after protein binding can be detected with high sensitivity by the CMOS image sensor. Therefore, this technique can be easily applied to smartphones or any clinical diagnostic devices for the detection of several biological entities, with high impact on the development of point-of-care applications.
Keyword
CMOS sensorsImmunoassaysIndium nanoparticlesInterferon gammaPhoton
ISSN
1618-2642
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s00216-011-5231-9
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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