Gene silencing by siRNA microhydrogels via polymeric nanoscale condensation

Cited 45 time in scopus
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Title
Gene silencing by siRNA microhydrogels via polymeric nanoscale condensation
Author(s)
C A Hong; S H Lee; J S Kim; J W Park; K H Bae; Hye Jung Mok; T G Park; H Lee
Bibliographic Citation
Journal of American Chemical Society, vol. 133, no. 35, pp. 13914-13917
Publication Year
2011
Abstract
The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanoparticles that exhibited superb cellular uptake efficiency and gene silencing activity.
ISSN
0002-7863
Publisher
Amer Chem Soc
DOI
http://dx.doi.org/10.1021/ja2056984
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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