Gene silencing by siRNA microhydrogels via polymeric nanoscale condensation
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- Title
- Gene silencing by siRNA microhydrogels via polymeric nanoscale condensation
- Author(s)
- C A Hong; S H Lee; J S Kim; J W Park; K H Bae; Hye Jung Mok; T G Park; H Lee
- Bibliographic Citation
- Journal of American Chemical Society, vol. 133, no. 35, pp. 13914-13917
- Publication Year
- 2011
- Abstract
- The first attempt to prepare biologically active siRNA-based microhydrogels is reported. The self-assembled microhydrogels were fabricated using sense/antisense complementary hybridization between single-stranded linear and Y-shaped trimeric siRNAs. The siRNA microhydrogels were condensed using a popular cationic polymer such as LPEI to form compact, stable siRNA/polymeric nanoparticles that exhibited superb cellular uptake efficiency and gene silencing activity.
- ISSN
- 0002-7863
- Publisher
- Amer Chem Soc
- Full Text Link
- http://dx.doi.org/10.1021/ja2056984
- Type
- Article
- Appears in Collections:
- 1. Journal Articles > Journal Articles
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