The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis

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Title
The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis
Author(s)
D H Lim; C T Oh; L Lee; J S Hong; S H Noh; Seungwoo Hwang; S Kim; S J Han; Y S Lee
Bibliographic Citation
FEBS Letters, vol. 585, no. 19, pp. 3079-3085
Publication Year
2011
Abstract
Small non-coding RNAs regulate gene expression in a sequence-specific manner. In Drosophila, Dicer-2 (Dcr-2) functions in the biogenesis of endogenous small interfering RNAs (endo-siRNAs). We identified 21 distinct proteins that exhibited a ≥1.5-fold change as a consequence of loss of dcr-2 function. Most of these were metabolic genes implicated in stress resistance and aging. dcr-2 Mutants had reduced lifespan and were hypersensitive to oxidative, endoplasmic reticulum, starvation, and cold stresses. Furthermore, loss of dcr-2 function led to abnormal lipid and carbohydrate metabolism. Our results suggest roles for the endo-siRNA pathway in metabolic regulation and defense against stress and aging in Drosophila.
Keyword
Dicer-2DrosophilaEndogenous siRNALifespanMetabolic homeostasisStress response
ISSN
0014-5793
Publisher
Wiley
DOI
http://dx.doi.org/10.1016/j.febslet.2011.08.034
Type
Article
Appears in Collections:
Korea Bioinformation Center > 1. Journal Articles
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