Synthesis and anti-platelet activity of obovatol derivatives

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Title
Synthesis and anti-platelet activity of obovatol derivatives
Author(s)
J H Kwak; S Lee; E S Park; J K In; J Song; Y J Kim; N S Choi; H Lee; Y P Yun; J T Hong; Young Shin Kwak; K H Min; J K Jung
Bibliographic Citation
Archives of Pharmacal Research, vol. 34, no. 7, pp. 1107-1112
Publication Year
2011
Abstract
Obovatol derivatives were synthesized and evaluated for anti-platelet activity. Three derivatives (1, 2, 4i) displayed equipotent activity to obovatolin arachidonic acid-induced platelet aggregation. An initial SAR study revealed that the introduction of alkoxy group in B ring could enhance inhibitory activity.
Keyword
Anti-platelet activityDerivativesObovatolSmall molecules
ISSN
0253-6269
Publisher
Pharmaceutical Soc Korea
DOI
http://dx.doi.org/10.1007/s12272-011-0708-9
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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