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- Title
- Inhibitory effect of ERK1/2 and AP-1 by hyperoside isolated from Acanthopanax sessiliflorus
- Author(s)
- S K Jung; T G Lim; J E Kim; S Byun; G W Kim; J N Choi; C H Lee; Bo Yeon Kim; K W Lee; H J Lee
- Bibliographic Citation
- Food Chemistry, vol. 130, no. 4, pp. 915-920
- Publication Year
- 2012
- Abstract
- Consumption of fruits and vegetables is correlated with a lower incidence of cancer. Here, we identified hyperoside as an active compound from Acanthopanax sessiliflorus, and investigated the effect of hyperoside on UVB-induced transactivation of activator protein 1 (AP-1) and on the mitogen-activated protein kinase signalling pathway in JB6 P + cells. Hyperoside inhibited UVB-induced AP-1 transactivation. It inhibited the UVB-induced phosphorylation of p90RSK. Kinase assays revealed that hyperoside significantly inhibited ERK1/2 activity. Furthermore, hyperoside bound to ERK1/2 to suppress its activity. In addition, phosphorylation of cAMP response element binding protein (CREB) and signal transducers and activators of transcription (STAT) 3 were suppressed by hyperoside. Overall, these results indicate that hyperoside may be a promising chemopreventive agent that acts by suppressing the transactivation of AP-1 and the phosphorylation of p90RSK, CREB, and STAT3 through the binding and inhibition of ERK1/2.
- Keyword
- Acanthopanax sessiliflorusAP-1ERK1/2Hyperoside
- ISSN
- 0308-8146
- Publisher
- Elsevier
- DOI
- http://dx.doi.org/10.1016/j.foodchem.2011.08.010
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
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