IL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells = 조혈줄기세포로부터 IL-22를 생산하는 innate lymphoid cell의 분화

Cited 3 time in scopus
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Title
IL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells = 조혈줄기세포로부터 IL-22를 생산하는 innate lymphoid cell의 분화
Author(s)
M S Kim; Won Sam Kim; Z H Piao; Sohyun Yun; S H Lee; Su Ui Lee; M Jeong; H N Sun; Young-Jun ParkHaiyoung JungSuk Ran Yoon; In Pyo Choi
Bibliographic Citation
Immunology Letters, vol. 141, no. 1, pp. 61-67
Publication Year
2011
Abstract
The IL-22 NKp46+ innate lymphoid cells, NCR22 cells, are very important for the early host defense against microbial pathogens. We show here that NCR22 cells were differentiated from Lin-CD127+CD117+ cells that were derived from hematopoietic precursor cells (HPCs) of mouse bone marrow cells. The combination of low concentrations of IL-23 and IL-15 induced differentiation of NCR22 cells from Lin-CD127+CD117+ cells. NCR22 cells expressed a large amount of IL-22 and RORγt, and they had poor cytolytic activity and produced little IFN-γ Lin-CD127+CD117+ cells were very similar to intestinal lamina propria LTi-like cells; both cells dominantly expressed RORγt and IL-22. Meanwhile, Lin-CD127-CD117+ cells that were also derived from HPCs did not express RORγt and IL-22, and they developed into conventional NK cells, not into NCR22 cells. These findings revealed that NCR22 cells can be differentiated from Lin-CD127+CD117+ cells which are derived from HPCs.
Keyword
DifferentiationIL-22NCR22NK cellsRORγt
ISSN
0165-2478
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.imlet.2011.07.007
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
Division of Research on National Challenges > Environmental diseases research center > 1. Journal Articles
Aging Convergence Research Center > 1. Journal Articles
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
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