The N-end rule pathway: emerging functions and molecular principles of substrate recognition

Cited 123 time in scopus
Metadata Downloads
Title
The N-end rule pathway: emerging functions and molecular principles of substrate recognition
Author(s)
S M Sriram; Bo Yeon Kim; Y T Kwon
Bibliographic Citation
Nature Reviews Molecular Cell Biology, vol. 12, no. 12, pp. 735-747
Publication Year
2011
Abstract
The N-end rule defines the protein-destabilizing activity of a given amino-terminal residue and its post-translational modification. Since its discovery 25 years ago, the pathway involved in the N-end rule has been thought to target only a limited set of specific substrates of the ubiquitin-proteasome system. Recent studies have provided insights into the components, substrates, functions and structural basis of substrate recognition. The N-end rule pathway is now emerging as a major cellular proteolytic system, in which the majority of proteins are born with or acquire specific N-terminal degradation determinants through protein-specific or global post-translational modifications.
ISSN
1471-0072
Publisher
Springer-Nature Pub Group
DOI
http://dx.doi.org/10.1038/nrm3217
Type
Article
Appears in Collections:
Ochang Branch Institute > Anticancer Agent Research Center > 1. Journal Articles
Files in This Item:
  • There are no files associated with this item.


Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.