Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression = 부탐벤의 골형성 효과

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Title
Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression = 부탐벤의 골형성 효과
Author(s)
H J Kim; M Park; Y M Han; Byoung-Mog Kwon; S H Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 24, pp. 7363-7366
Publication Year
2011
Abstract
As the primary step for 'drug repositioning', we evaluated the effect of 2000 drugs and drug candidates on the commitment of bi-potential mesenchymal precursor C2C12 cells into osteoblasts in the presence of bone morphogenetic protein (BMP)-2 and found that butamben enhanced BMP-2-stimulated induction of alkaline phosphatase, a biomarker of osteoblastogenesis. Investigating the underlying mechanism of its anabolic actions, we found anabolic action of its derivative (compound 4) relies on BMP-2 signaling and mRNA induction of BMPs and voltage-gated potassium channels.
Keyword
Bone morphogenetic proteinButambenDrug repositioningOsteoblastogenesisVoltage-gated potassium channel
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2011.10.020
Type
Article
Appears in Collections:
Division of Biomedical Research > Genome Editing Research Center > 1. Journal Articles
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