Identification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes

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Title
Identification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes
Author(s)
D H Lee; Youra Lee; Joohyun Ryu; Sung Goo Park; S Cho; J J Lee; C Choi; Byoung Chul Park
Bibliographic Citation
Molecules and Cells, vol. 31, no. 6, pp. 563-571
Publication Year
2011
Abstract
In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, urokinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.
Keyword
AATAGR2DBPgastric cancermetastasisproteome
ISSN
1016-8478
Publisher
South Korea
DOI
http://dx.doi.org/10.1007/s10059-011-1053-z
Type
Article
Appears in Collections:
Division of Biomedical Research > Disease Target Structure Research Center > 1. Journal Articles
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