Open Access@KRIBBDivision of A.I. & Biomedical ResearchOrphan Disease Therapeutic Target Research Center1. Journal Articles
Identification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes
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- Title
- Identification of proteins differentially expressed in gastric cancer cells with high metastatic potential for invasion to lymph nodes
- Author(s)
- D H Lee; Youra Lee; Joohyun Ryu; Sung Goo Park; S Cho; J J Lee; C Choi; Byoung Chul Park
- Bibliographic Citation
- Molecules and Cells, vol. 31, no. 6, pp. 563-571
- Publication Year
- 2011
- Abstract
- In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, urokinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.
- ISSN
- 1016-8478
- Publisher
- Korea Soc-Assoc-Inst
- Full Text Link
- http://dx.doi.org/10.1007/s10059-011-1053-z
- Type
- Article
- Appears in Collections:
- Division of A.I. & Biomedical Research > Orphan Disease Therapeutic Target Research Center > 1. Journal Articles
Critical Diseases Diagnostics Convergence Research Center > 1. Journal Articles
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