Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum
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- Title
- Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum
- Author(s)
- B W Choi; Hyun Sun Lee; K B Lee; B H Lee
- Bibliographic Citation
- Phytotherapy Research, vol. 25, no. 7, pp. 1041-1045
- Publication Year
- 2011
- Abstract
- The pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a target for the treatment of obesity and type 2 diabetes. Chromatographic analysis of the brown alga, Pachydictyon coriaceum, led to the isolation of diterpene dictyol E and hydroxyisocrenulatin. Pharmacological assay of these compounds demonstrated DGAT inhibitory activity with IC50 values of 46.0 μM and 23.3 μM, respectively.
- Keyword
- Acyl CoA:diacylglycerol acyltransferase (DGAT)HypertriglyceridemiaObesityPachydictyon coriaceumTerpenoidsType 2 diabetes
- ISSN
- 0951-418X
- Publisher
- Wiley
- Full Text Link
- http://dx.doi.org/10.1002/ptr.3391
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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