Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum

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Title
Isolation of diacyl glycerol acyl transferase (DGAT) inhibitors from Pachydictyon coriaceum
Author(s)
B W Choi; Hyun Sun Lee; K B Lee; B H Lee
Bibliographic Citation
Phytotherapy Research, vol. 25, no. 7, pp. 1041-1045
Publication Year
2011
Abstract
The pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a target for the treatment of obesity and type 2 diabetes. Chromatographic analysis of the brown alga, Pachydictyon coriaceum, led to the isolation of diterpene dictyol E and hydroxyisocrenulatin. Pharmacological assay of these compounds demonstrated DGAT inhibitory activity with IC50 values of 46.0 μM and 23.3 μM, respectively.
Keyword
Acyl CoA:diacylglycerol acyltransferase (DGAT)HypertriglyceridemiaObesityPachydictyon coriaceumTerpenoidsType 2 diabetes
ISSN
0951-418X
Publisher
Wiley
DOI
http://dx.doi.org/10.1002/ptr.3391
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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