Evolutionary diversification of DYX1C1 transcripts via an HERV-H LTR integration event

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Title
Evolutionary diversification of DYX1C1 transcripts via an HERV-H LTR integration event
Author(s)
Y J Kim; Jae Won HuhDae Soo Kim; K Han; H M Kim; H S Kim
Bibliographic Citation
Genes & Genetic Systems, vol. 86, no. 4, pp. 277-284
Publication Year
2011
Abstract
DYX1C1 is a candidate gene for developmental dyslexia and has three alternative pre-mRNA spliced forms in the human genome. One of the transcripts contains an HERV-H LTR that could affect the expression level of DYX1C1. We speculate that the HERV-H LTR integrated into the DYX1C1 locus in the catarrhine lineage after its divergence from the platyrrhine lineage. Reverse transcription-PCR of the HERV-H LTR-related transcript produced four alternative forms from several human tissues. All of alternative forms were also identified in various rhesus macaque tissues. Through sequencing analysis of various primate DNA samples, we found that a part of the HERV-H LTR sequence was duplicated within the DYX1C1 exon 9 only in catarrhines. However, the duplication event did not cause frameshift mutation of the DYX1C1 transcript. Taken together, this HERV-H LTR insertion into DYX1C1 has contributed to transcript diversification of DYX1C1 during primate evolution.
Keyword
Alternative splicingDuplicationDYX1C1 geneExonizationHERV-H
ISSN
1341-7568
Publisher
Genetics Soc Japan
DOI
http://dx.doi.org/10.1266/ggs.86.277
Type
Article
Appears in Collections:
Ochang Branch Institute > Division of National Bio-Infrastructure > National Primate Research Center > 1. Journal Articles
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