Abietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity

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Title
Abietane diterpenoids of Rosmarinus officinalis and their diacylglycerol acyltransferase-inhibitory activity
Author(s)
L Cui; Mun-Ock Kim; Jihee Seo; I S Kim; N Y Kim; S H Lee; JeongJun Park; J Kim; Hyun Sun Lee
Bibliographic Citation
Food Chemistry, vol. 132, no. 4, pp. 1775-1780
Publication Year
2012
Abstract
Inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT) has been proposed as one of the drug targets for treating obesity and type 2 diabetes. Bioassay-guided fractionation of the MeOH-soluble extract of Rosmarinus officinalis yielded two new diacylglycerol acyltransferase (DGAT) inhibitory-abietane diterpenoids, 7β-hydroxy-20-deoxo-rosmaquinone (1) and 7β-methoxy-20-deoxo-rosmanol (2), along with six known components, carnosol (3), 7α-methoxyrosmanol (4), 7β-methoxyrosmanol (5), 12-methoxy-canosic acid (6), rosmanol (7), and rosmadial (8). Compounds 1-8 inhibited DGAT1 activity, with the IC 50 values ranging from 39.5 ± 0.6 to 144.2 ± 3.1 μM. In particular, carnosol (3), which is one of the major compounds of MeOH-soluble extract of R. officinalisexhibits inhibition of de novo intracellular triacylglycerol synthesis in human hepatocyte HepG2 cells.
Keyword
Abietane diterpenoidCarnosolDiacylglycerol acyltransferaseRosmarinus officinalisTriacylglycerol synthesis
ISSN
0308-8146
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.foodchem.2011.11.138
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Product Research Center > 1. Journal Articles
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