Hypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy

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dc.contributor.authorT R Kim-
dc.contributor.authorEun Wie Cho-
dc.contributor.authorS G Paik-
dc.contributor.authorI G Kim-
dc.date.accessioned2017-04-19T09:28:52Z-
dc.date.available2017-04-19T09:28:52Z-
dc.date.issued2012-
dc.identifier.issn0014-5793-
dc.identifier.uri10.1016/j.febslet.2011.12.036ko
dc.identifier.urihttps://oak.kribb.re.kr/handle/201005/10608-
dc.description.abstractChemo- or radiation-resistance in tumors caused by hypoxia often undermines efficacy of cancer therapy. Thus, therapies that overcome cellular resistance during hypoxia are necessary. SM22α is an actin-binding protein found in smooth muscle, fibroblasts, and some epithelium. We demonstrate that SM22α is induced in A549 non-small cell lung carcinoma cells by hypoxia and its overexpression increased chemo- and radiation-resistance. Hypoxia-mediated induction of SM22α expression is hypoxia-inducible factor-independent. Moreover, SM22α overexpression enhances tumor cell growth and activates the IGF1R/PI3K/Akt pathway via direct interaction with IGF1Rβ. Our results suggest SM22α as a novel regulator of hypoxic survival pathway of A549 NSCLC cells. Structured summary of protein interactions: IGFR1 Beta physically interacts with SM22 alpha by anti bait coimmunoprecipitation (View Interaction: 1, 2).-
dc.publisherWiley-
dc.titleHypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy-
dc.title.alternativeHypoxia-induced SM22α in A549 cells activates the IGF1R/PI3K/Akt pathway, conferring cellular resistance against chemo- and radiation therapy-
dc.typeArticle-
dc.citation.titleFEBS Letters-
dc.citation.number4-
dc.citation.endPage309-
dc.citation.startPage303-
dc.citation.volume586-
dc.contributor.affiliatedAuthorEun Wie Cho-
dc.contributor.alternativeName김태림-
dc.contributor.alternativeName조은위-
dc.contributor.alternativeName백상기-
dc.contributor.alternativeName김인규-
dc.identifier.bibliographicCitationFEBS Letters, vol. 586, no. 4, pp. 303-309-
dc.identifier.doi10.1016/j.febslet.2011.12.036-
dc.subject.keywordChemo-resistance-
dc.subject.keywordHypoxia-
dc.subject.keywordIGF1Rβ-
dc.subject.keywordPI3K/Akt-
dc.subject.keywordSM22-
dc.subject.localchemoresistance-
dc.subject.localChemoresistance-
dc.subject.localChemo-resistance-
dc.subject.localhypoxia-
dc.subject.localHypoxia-
dc.subject.localIGF1Rβ-
dc.subject.localPI3K/AKT-
dc.subject.localPI3K/Akt-
dc.subject.localSM22-
dc.description.journalClassY-
Appears in Collections:
Division of Biomedical Research > Rare Disease Research Center > 1. Journal Articles
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