Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375 = Penicillium verruculosum이 생산하는 새로운 항세균 enoyl-ACP reductase 저해물질

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Title
Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375 = Penicillium verruculosum이 생산하는 새로운 항세균 enoyl-ACP reductase 저해물질
Author(s)
Nyung Kim; M J Sohn; Chang-Jin Kim; H J Kwon; Won Gon Kim
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 22, no. 7, pp. 2503-2506
Publication Year
2012
Abstract
New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC 50 of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 μg/mL, respectively.
Keyword
Enoyl-ACP reductaseFabIInhibitorPenicillium verruculosumStaphylococcus aureus
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2012.02.001
Type
Article
Appears in Collections:
Division of Research on National Challenges > Infectious Disease Research Center > 1. Journal Articles
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