Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells

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Title
Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells
Author(s)
Hee Sung Chae; Young Won Chin
Bibliographic Citation
Immunopharmacology and Immunotoxicology, vol. 34, no. 2, pp. 250-255
Publication Year
2012
Abstract
Lambertianic acid is a bioactive diterpene found in the leaves of Thuja orientalis. Its effect on the bone marrow-derived mast cell (BMMC) mediated allergy and inflammation mechanism remains unknown. In this study, lambertianic acid was evaluated for its effect on the allergicmediators, including prostaglandin D2 (PGD2), leukotriene C4 (LTC4), β-hexosaminidase (β-Hex) and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that lambertianic acidinhibited the production of interleukin-6 (IL-6), PGD2 and LTC4, the expression of COX-2 and the degranulation of β-hexosaminidase in the PMA plus calcimycin-induced BMMCs. Taken together, these findings implied that lambertianic acid may possess the potential in the treatment of allergy.
Keyword
β-hexosaminidaseAllergyBone marrow-derived mast cellCOX-2IL-6Lambertianic acidLTC4PGD2
ISSN
0892-3973
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.3109/08923973.2011.600763
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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