Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells
Cited 30 time in 
Metadata Downloads
Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Hee Sung Chae | - |
| dc.contributor.author | Young Won Chin | - |
| dc.date.accessioned | 2017-04-19T09:28:55Z | - |
| dc.date.available | 2017-04-19T09:28:55Z | - |
| dc.date.issued | 2012 | - |
| dc.identifier.issn | 0892-3973 | - |
| dc.identifier.uri | 10.3109/08923973.2011.600763 | ko |
| dc.identifier.uri | https://oak.kribb.re.kr/handle/201005/10627 | - |
| dc.description.abstract | Lambertianic acid is a bioactive diterpene found in the leaves of Thuja orientalis. Its effect on the bone marrow-derived mast cell (BMMC) mediated allergy and inflammation mechanism remains unknown. In this study, lambertianic acid was evaluated for its effect on the allergicmediators, including prostaglandin D2 (PGD2), leukotriene C4 (LTC4), β-hexosaminidase (β-Hex) and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that lambertianic acidinhibited the production of interleukin-6 (IL-6), PGD2 and LTC4, the expression of COX-2 and the degranulation of β-hexosaminidase in the PMA plus calcimycin-induced BMMCs. Taken together, these findings implied that lambertianic acid may possess the potential in the treatment of allergy. | - |
| dc.publisher | T&F (Taylor & Francis) | - |
| dc.title | Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells | - |
| dc.title.alternative | Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells | - |
| dc.type | Article | - |
| dc.citation.title | Immunopharmacology and Immunotoxicology | - |
| dc.citation.number | 2 | - |
| dc.citation.endPage | 255 | - |
| dc.citation.startPage | 250 | - |
| dc.citation.volume | 34 | - |
| dc.contributor.affiliatedAuthor | Hee Sung Chae | - |
| dc.contributor.alternativeName | 채희성 | - |
| dc.contributor.alternativeName | 진영원 | - |
| dc.identifier.bibliographicCitation | Immunopharmacology and Immunotoxicology, vol. 34, no. 2, pp. 250-255 | - |
| dc.identifier.doi | 10.3109/08923973.2011.600763 | - |
| dc.subject.keyword | β-hexosaminidase | - |
| dc.subject.keyword | Allergy | - |
| dc.subject.keyword | Bone marrow-derived mast cell | - |
| dc.subject.keyword | COX-2 | - |
| dc.subject.keyword | IL-6 | - |
| dc.subject.keyword | Lambertianic acid | - |
| dc.subject.keyword | LTC4 | - |
| dc.subject.keyword | PGD2 | - |
| dc.subject.local | β-hexosaminidase | - |
| dc.subject.local | Allergy | - |
| dc.subject.local | allergy | - |
| dc.subject.local | Bone marrow-derived mast cell | - |
| dc.subject.local | Bone Marrow Derived Mast Cell | - |
| dc.subject.local | bone-marrow derived mast cell | - |
| dc.subject.local | Bone marrow derived mast cell | - |
| dc.subject.local | COX-2 | - |
| dc.subject.local | Cox-2 | - |
| dc.subject.local | IL6 | - |
| dc.subject.local | interukin -6 | - |
| dc.subject.local | Interleukin-6 (IL-6) | - |
| dc.subject.local | IL-6 | - |
| dc.subject.local | Il-6 | - |
| dc.subject.local | interleukin-6 | - |
| dc.subject.local | interleukin-6 (IL-6) | - |
| dc.subject.local | Interleukin-6 | - |
| dc.subject.local | Lambertianic acid | - |
| dc.subject.local | LTC4 | - |
| dc.subject.local | PGD2 | - |
| dc.description.journalClass | Y | - |
- Appears in Collections:
- 1. Journal Articles > Journal Articles
- Files in This Item:
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.