Tigliane diterpene esters with IFN γ-inducing activity from the leaves of Aleurites fordii

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Title
Tigliane diterpene esters with IFN γ-inducing activity from the leaves of Aleurites fordii
Author(s)
Y H Pei; Jae Wha Kim; Ho Bum Kang; Hyeong Kyu Lee; C S Kim; Hyuk Hwan Song; Y W Chin; Sei Ryang Oh
Bibliographic Citation
Bioorganic & Medicinal Chemistry Letters, vol. 22, no. 6, pp. 2318-2320
Publication Year
2012
Abstract
Bioactivity-guided fractionation on the leaves of Aleurites fordii led to the isolation of a new tigliane diterpene ester, 12-O-hexadecanoyl-7-oxo-5-ene- 16-hydroxyphorbol-13-acetate (1) along with four known compounds, 12-O-hexadecanoyl-7-oxo-5-ene-phorbol-13-acetate (2), 12-O-hexadecanoyl-phorbol- 13-acetate (3), 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate (4), and 12-O-hexadecanoyl-4-deoxy-4α-16-hydroxyphorbol-13-acetate (5). The structures of these compounds were determined by interpretation of NMR (1D and 2D) spectroscopic data and MS data. All the isolates were evaluated for their effects on the induction of IFN-γ in NK92 cells. Compounds 3 and 4 exhibited the most potent responses in IFN-γ induction, comparable to the positive control, phorbol 12-myristate 13-acetate (PMA).
Keyword
Aleurites fordiiEuphorbiaceaeIFN-γ productionPhorbolTigliane diterpene
ISSN
0960-894X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bmcl.2012.01.057
Type
Article
Appears in Collections:
Division of Biomedical Research > Immunotherapy Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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