Ethanol extract of Elaeocarpus petiolatus inhibits lipopolysaccharide-induced inflammation in macrophage cells = 엘리오카퍼스 페티오라투스의 LPS-유도 염증억제

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Title
Ethanol extract of Elaeocarpus petiolatus inhibits lipopolysaccharide-induced inflammation in macrophage cells = 엘리오카퍼스 페티오라투스의 LPS-유도 염증억제
Author(s)
Ok-Kyoung KwonKyung Seop Ahn; Ji Won Park; Ha young Jang; Hyouk Joung; Hyeong Kyu Lee; Sei Ryang Oh
Bibliographic Citation
Inflammation, vol. 35, no. 2, pp. 535-544
Publication Year
2012
Abstract
Elaeocarpus petiolatus is known to exert active oxygen scavenging, anti-aging, and whitening actions. However, the biological effects of E. petiolatus on inflammation and the underlying mechanisms are yet to be established. In the present study, we investigated the anti-inflammatory effects of the ethanol extract from E. petiolatus (EPE) bark in murine Raw264.7 macrophages stimulated with lipopolysaccharide (LPS). EPE inhibited the production of PGE2, TNF-α, and IL-1β in a dose-dependent manner in Raw264.7 cells stimulated with LPS. The decrease in PGE2 production was correlated with reduced COX-2 expression. Furthermore, EPE suppressed the phosphorylation of extracellular signal-related kinases (ERK), c-Jun N-terminal kinase (JNK), and p38 as well as translocation of the NF-κB p65 subunit from the cytosol to nucleus. Our results suggest that EPE exerts anti-inflammatory activity through inhibition of inflammatory mediators, such as PGE2, TNF-α, and IL-1β, and downregulation of COX-2 via suppression of NF-κB translocation and phosphorylation of ERK, JNK, and p38 in LPS-stimulated Raw264.7 cells.
Keyword
COX-2Elaeocarpus petiolatusinflammationMAPKNF-kappaB
ISSN
0360-3997
Publisher
Springer
DOI
http://dx.doi.org/10.1007/s10753-011-9343-3
Type
Article
Appears in Collections:
Ochang Branch Institute > Natural Medicine Research Center > 1. Journal Articles
Ochang Branch Institute > 1. Journal Articles
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