Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition = 소목으로부터 분리한 homoisoflavonoids의 viral neuraminidases 저해활성

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Title
Homoisoflavonoids from Caesalpinia sappan displaying viral neuraminidases inhibition = 소목으로부터 분리한 homoisoflavonoids의 viral neuraminidases 저해활성
Author(s)
Hyung Jae Jung; Young Min Kim; Jang Hoon Kim; J Y Kim; Ji Young ParkSu-Jin ParkYoung Bae RyuWoo Song Lee
Bibliographic Citation
Biological & Pharmaceutical Bulletin, vol. 35, no. 5, pp. 786-790
Publication Year
2012
Abstract
In this study, twelve neuraminidase (NA) inhibitory compounds 1-12 were isolated from heartwood of Caesalpinia sappan on the basis of their biological activities against three types of viral NAs. Of isolated homoisoflavonoids, sappanone A (2) showed the most potent NAs inhibitory activities with IC 50 values of 0.7 μM [H1N1], 1.1 μM [H3N2], and 1.0 μM [H9N2], respectively, whereas saturated homoisoflavonoid (3) did not show significantly inhibition. This result revealed that α,β-unsaturated carbonyl group in A-ring was the key requirements for viral NAs inhibitory activity. In our enzyme kinetic study, all NA inhibitors screened were found to be reversible noncompetitive types.
Keyword
α,β-unsaturated carbonylCaesalpinia sappanHomoisoflavonoidNeuraminidase
ISSN
0918-6158
Publisher
Pharmaceutical Soc Japan
DOI
http://dx.doi.org/10.1248/bpb.35.786
Type
Article
Appears in Collections:
Jeonbuk Branch Institute > Functional Biomaterial Research Center > 1. Journal Articles
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