Inhibitory effect of melanogenesis by 5-pentyl-2-furaldehyde isolated from Clitocybe sp.
Cited 1 time in 
Metadata Downloads
- Title
- Inhibitory effect of melanogenesis by 5-pentyl-2-furaldehyde isolated from Clitocybe sp.
- Author(s)
- Y H Kim; Soo-Jin Choo; In Ja Ryoo; Bo Yeon Kim; Jong Seog Ahn; Ick-Dong Yoo
- Bibliographic Citation
- Journal of Microbiology and Biotechnology, vol. 22, no. 6, pp. 814-817
- Publication Year
- 2012
- Abstract
- In the continued search for melanogenesis inhibitors from microbial metabolites, we found that the culture broth of Clitocybe sp. MKACC 53267 inhibited melanogenesis in B16F10 melanoma cells. The active component was purified by solvent extraction, silica gel chromatography, Sephadex LH-20 column chromatography, and finally by preparative HPLC. Its structure was determined as 5-pentyl-2-furaldehyde on the basis of the UV, NMR, and MS spectroscopic analysis. The 5-pentyl-2-furaldehyde potently inhibited melanogenesis in B16F10 cells with an IC 50 value of 8.4 μg/ml, without cytotoxicity.
- ISSN
- 1017-7825
- Publisher
- Korea Soc-Assoc-Inst
- Full Text Link
- http://dx.doi.org/10.4014/jmb.1101.01053
- Type
- Article
- Appears in Collections:
- Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
- Files in This Item:
There are no files associated with this item.
Items in OpenAccess@KRIBB are protected by copyright, with all rights reserved, unless otherwise indicated.