Inhibitory effect of melanogenesis by 5-pentyl-2-furaldehyde isolated from Clitocybe sp.

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Title
Inhibitory effect of melanogenesis by 5-pentyl-2-furaldehyde isolated from Clitocybe sp.
Author(s)
Y H Kim; Soo-Jin Choo; In Ja RyooBo Yeon KimJong Seog Ahn; Ick-Dong Yoo
Bibliographic Citation
Journal of Microbiology and Biotechnology, vol. 22, no. 6, pp. 814-817
Publication Year
2012
Abstract
In the continued search for melanogenesis inhibitors from microbial metabolites, we found that the culture broth of Clitocybe sp. MKACC 53267 inhibited melanogenesis in B16F10 melanoma cells. The active component was purified by solvent extraction, silica gel chromatography, Sephadex LH-20 column chromatography, and finally by preparative HPLC. Its structure was determined as 5-pentyl-2-furaldehyde on the basis of the UV, NMR, and MS spectroscopic analysis. The 5-pentyl-2-furaldehyde potently inhibited melanogenesis in B16F10 cells with an IC 50 value of 8.4 μg/ml, without cytotoxicity.
Keyword
5-penty 1-2-furaldehydeB16F10 melanomaClitocybe spMelanogenesis
ISSN
1017-7825
Publisher
Korea Soc-Assoc-Inst
DOI
http://dx.doi.org/10.4014/jmb.1101.01053
Type
Article
Appears in Collections:
Ochang Branch Institute > Chemical Biology Research Center > 1. Journal Articles
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