Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level

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Title
Pyruvate kinase M2 promotes the growth of gastric cancer cells via regulation of Bcl-xL expression at transcriptional level
Author(s)
Oh Hyung Kwon; T W Kang; Jeong Hwan KimMirang Kim; S M Noh; K S Song; Hyang Sook Yoo; W H Kim; Z Xie; D Pocalyko; Seon-Young Kim; Yong Sung Kim
Bibliographic Citation
Biochemical and Biophysical Research Communications, vol. 423, no. 1, pp. 38-44
Publication Year
2012
Abstract
PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase that promotes aerobic glycolysis. Here, we describe an important role for PKM2 in regulating the survival of gastric cancer (GC) cells. We showed that PKM2 was overexpressed in gastric tumor tissues compared to normal tissues and its expression level was associated with poor survival of gastric cancer patients. We also showed that PKM2 affected cell survival by regulating Bcl-xL at the transcriptional level. PKM2 knockdown partially affected the stability of NF-kB subunit p65, suggesting that post-translational regulation of p65 by PKM2 is one of plausible mechanisms for the increased cell growth. Therefore, PKM2 may function as an upstream molecule that regulates p65 function and thus enhances the growth of tumor cells.
Keyword
Bcl-xLGastric cancerNF-κBPKM2
ISSN
0006-291X
Publisher
Elsevier
DOI
http://dx.doi.org/10.1016/j.bbrc.2012.05.063
Type
Article
Appears in Collections:
Aging Convergence Research Center > 1. Journal Articles
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