Identification of novel metastasis suppressor signaling pathways for breast cancer

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Title
Identification of novel metastasis suppressor signaling pathways for breast cancer
Author(s)
A J Minn; E Bevilacqua; Ji Eun Yun; M R Rosner
Bibliographic Citation
Cell Cycle, vol. 11, no. 13, pp. 2452-2457
Publication Year
2012
Abstract
Cancer lethality is mainly caused by metastasis. Therefore, understanding the nature of the genes involved in this process has become a priority. Given the heterogeneity of mutations in cancer cells, considerable focus has been directed toward characterizing metastasis genes in the context of relevant signaling pathways rather than treating genes as independent and equal entities. One signaling cascade implicated in the regulation of cell growth, invasion and metastasis is the MAP kinase pathway. Raf kinase inhibitory protein (RKIP) functions as an inhibitor of the MAP kinase pathway and is a metastasis suppressor in different cancer models. By utilizing statistical analysis of clinical data integrated with experimental validation, we recently identified components of the RKIP signaling pathway relevant to breast cancer metastasis. Using the RKIP pathway as an example, we show how prior biological knowledge can be efficiently combined with genome-wide patient data to identify gene regulatory mechanisms that control metastasis.
Keyword
Breast cancerGene set analysisGene set enrichment analysisGene signatureInvasionMetastasisRaf kinase inhibitory proteinRandom forestsSignaling pathway
ISSN
1538-4101
Publisher
T&F (Taylor & Francis)
DOI
http://dx.doi.org/10.4161/cc.20624
Type
Article
Appears in Collections:
1. Journal Articles > Journal Articles
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