Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells

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Title
Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells
Author(s)
Hyuk Hwan Song; Hee Sung Chae; Sei Ryang Oh; Hyeong Kyu Lee; Y W Chin
Bibliographic Citation
American Journal of Chinese Medicine, vol. 40, no. 5, pp. 1073-1084
Publication Year
2012
Abstract
In this study, the anti-inflammatory and anti-allergic effects of the chloroform-soluble extract of Agaricus blazei in mouse bone marrow-derived mast cells (BMMCs) were investigated. The chloroform-soluble extract inhibited IL-6 production in PMA plus A23187-stimulated BMMCs, and down-regulated the phosphorylation of Akt. In addition, this extract demonstrated inhibition of the degranulation of β-hexosaminidase and the production of IL-6, prostaglandin D 2 and leukotriene C 4 in PMA plus A23187-induced BMMCs. In conclusion, the chloroform-soluble extract of Agaricus blazei exerted anti-inflammatory and anti-allergic activities mediated by influencing IL-6, prostaglandin D 2, leukotriene C 4, and the phosphorylation of Akt.
Keyword
Agaricus blazeiAktBone Marrow Derived Mast CellDegranulationInterleukin-6Leukotriene C 4Prostaglandin D 2
ISSN
0192-415X
Publisher
World Scientific Publ Co Pte Ltd
DOI
http://dx.doi.org/10.1142/S0192415X12500796
Type
Article
Appears in Collections:
Ochang Branch Institute > 1. Journal Articles
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